Effect of diabetes mellitus on antibody levels in elderly individuals after vaccination with inactivated SARS-CoV-2 vaccine  

作　　者：Wen Guo Yu Cao Yingmei Feng 

机构地区：[1]Office of the Party Committee,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China [2]Department of Science and Technology,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China

出　　处：《感染控制(英文)》2024年第1期60-67,共8页

摘　　要：Background We explored the influence of diabetes on the antibody levels of elderly individuals after inoculation with an inactivated vaccine against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the factors that influenced IgG antibody levels 30 d after the second vaccine dose.Methods A total of 55 elderly people in Beijing You'an Hospital from September to December 2021 were selected and divided into diabetes(n=13)and non-diabetes(n=42)groups according to prevalence.IgG and IgM antibodies were detected with the colloidal gold method,and neutralizing antibodies were detected with a pseudovirus neutralization test.The IgG antibody levels at 30 and 180 d after two doses of inactivated SARS-CoV-2 vaccine and the geometric mean titers(GMTs)at 7 and 14 d after booster vaccination were compared between the groups.We analyzed factors influencing IgG antibody levels at 30 days after inoculation by multiple linear regression.Results Of the participants,21 were male and 34 were female,with ages ranging from 60 to 76 years(average:65.3±3.8 years).The IgG antibody levels and antibody positivity rates at 30 and 180 d after inoculation were significantly lower in the diabetes group than in the non-diabetes group(1.28[0.21,3.94]versus 4.47[2.48,5.99]and 53.85%versus 80.95%,respectively;P<0.05).There were no significant differences in IgM and IgG antibody levels or positivity rates between the two groups 180 d after vaccination,or in neutralizing antibody GMT between the two groups at 7 and 14 d(P>0.05).Multiple linear regression analysis showed that diabetes was an influencing factor for IgG antibody level(P<0.05),and IgG antibody level decreased with diabetes.Conclusions Diabetes can reduce short-term antibody levels induced by inactivated SARS-CoV-2 vaccine,but it does not affect long-term antibody levels.

关 键 词：inactivated vaccine against SARS-CoV-2 DIABETES IgG antibody neutralizing antibody 

分 类 号：R58[医药卫生—内分泌]