胸腺萎缩在脓毒症免疫紊乱中的研究进展  

Research progress in sepsis immune disorder:thymic atrophy

作　　者：陈曦[1,2] 吴宗盛[1,2,3] 郑明珠 邱海波[1,2] Chen Xi;Wu Zongsheng;Zheng Mingzhu;Qiu Haibo(Jiangsu Provincial Key Laboratory of Critical Care Medicine,Department of Critical Care Medicine,Zhongda Hospital,Southeast University,Nanjing 210009,China;School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]江苏省重症医学重点实验室,东南大学附属中大医院重症医学科,南京210009 [2]东南大学医学院,南京210009 [3]江苏省重症医学重点实验室,东南大学附属中大医院急诊医学科,南京210009

出　　处：《中华重症医学电子杂志》2024年第4期379-383,共5页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金重点项目(81930058);国家自然科学基金项目(82171717);科技部国家重点研发计划项目(2020YFC083700);江苏省重症医学重点实验室项目(BM2020004);中央高校基本科研业务费专项资金项目(2242022K4007)

摘　　要：脓毒症是危重症患者的重要死亡原因,免疫紊乱是脓毒症发生发展的关键。生理及病理状态下胸腺萎缩的发生均会损害机体的免疫功能。多项研究表明脓毒症会导致急剧的胸腺萎缩,主要表现为胸腺淋巴细胞的凋亡和胸腺上皮细胞的损伤增加,是脓毒症免疫功能紊乱的重要机制之一。更重要的是,胸腺功能的可逆性恢复可能与脓毒症患者预后密切相关。深入了解脓毒症时发生急性胸腺萎缩的机制并提出促进胸腺恢复的相关策略可能为脓毒症免疫治疗提供新的思路。One of the major causes of death in critically ill patients is sepsis,which results from a dysregulated immune response to infection.Both physiological and pathological development of thymus atrophy impairs body immune function.Multiple studies have shown that sepsis also leads to dramatically thymic atrophy,mainly manifested by increased apoptosis of thymocytes and damage of thymic epithelial cells,which is one of the important mechanisms of immune dysfunction in sepsis.More importantly,reversible recovery of thymus function may be closely related to prognosis of sepsis patients.An in-depth understanding of the mechanisms of acute thymic atrophy in sepsis and the development of related strategies to promote thymic recovery may provide new insights for sepsis immunotherapy.

关 键 词：脓毒症 胸腺萎缩 免疫紊乱 

分 类 号：R631[医药卫生—外科学] R459.7[医药卫生—临床医学]