成人脓毒症患者β-内酰胺类抗生素延长输注专家共识  

Experts consensus on extended infusion ofβ-lactam antibiotics in adult sepsis patients

作　　者：成人脓毒症患者β-内酰胺类抗生素延长输注专家共识编写组 陈玉国[2] 于凯江 吕奔 王昊[2] 张学海[2] 韩辉[2] 秦伟栋[2] Task Force on Experts Consensus on Extended Infusion ofβ-Lactam Antibiotics in Adult Sepsis Patients;Chen Yuguo;Yu Kaijiang;Lyv Ben;Wang Hao

机构地区：[1]不详 [2]山东大学齐鲁医院 [3]哈尔滨医科大学附属第一医院 [4]中南大学湘雅二医院

出　　处：《中华重症医学电子杂志》2024年第4期313-324,共12页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金项目(82072231);山东省自然科学基金项目(ZR2023YQ068);泰山学者青年专家项目(tsqn202103165)

摘　　要：脓毒症是宿主对感染的异常反应所引起的危及生命的器官功能障碍综合征,早期和恰当的抗感染治疗可以改善其预后。β-内酰胺类抗生素是治疗脓毒症的常用抗感染药物。β-内酰胺类抗生素延长输注时间是一种简便有效的优化药物PK/PD,提高药物治疗效果的方法。本共识就成人脓毒症患者β-内酰胺类抗生素延长输注时间的基础理论、有效性、安全性及临床使用要点展开讨论,总结现有的循证医学证据,以供临床实践参考。Sepsis is a pathologic syndrome of life-threatening organ dysfunction caused by a dysregulated host immune response to infection.Early and appropriate anti-infection treatment can improve the prognosis.β-lactam antibiotics are common antibiotics for the treatment of sepsis.Extended infusion ofβ-lactam antibiotics is a simple and effective method to optimize pharmacokinetic/pharmacodynamics and improve the efficiency.In the experts consensus,we discuss the basic theory,efficiency,safety,and clinical application on extended infusion ofβ-lactam antibiotics in adult sepsis patients,and summarize the evidence-based medicine for reference.

关 键 词：脓毒症 Β-内酰胺类抗生素 延长输注 持续输注 

分 类 号：R459.7[医药卫生—急诊医学]