单核/巨噬细胞来源的细胞外囊泡在急性呼吸窘迫综合征中的研究进展  

Research progress on extracellular vesicle derived from monocytes/macrophages in acute respiratory distress syndrome

作　　者：李松栗 黄蔚 巢杰 杨毅[1] 邱海波[1] Li Songli;Huang Wei;Chao Jie;Yang Yi;Qiu Haibo(Jiangsu Provincial Key Laboratory of Critical Care Medicine,Zhongda hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]江苏省重症医学重点实验室,东南大学附属中大医院重症医学科,南京210009

出　　处：《中华重症医学电子杂志》2024年第3期253-257,共5页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金重点项目(81930058);国家自然科学基金专项(82341032);科技部国家重点研发计划项目(2022YFC2504400)

摘　　要：单核/巨噬细胞是肺部对抗病原微生物和外来刺激的第一道防线,可通过细胞外囊泡(EV)在急性呼吸窘迫综合征(ARDS)肺部免疫炎症反应的发生发展中扮演着重要角色。本文就单核/巨噬细胞来源的EV在ARDS中作用机制的相关研究进展以及其在ARDS诊治中潜在的临床意义进行综述。Monocytes/macrophages,as the first line of defense against stimuli in the lungs,play an undeniable role in mediating the occurrence and development of immune inflammatory responses in the lungs of acute respiratory distress syndrome(ARDS)through extracellular vesicle(EV).This article reviews the research progress on the mechanism of EV derived from monocytes/macrophages in ARDS and their potential clinical significance in the diagnosis and treatment of ARDS.

关 键 词：急性呼吸窘迫综合征 细胞外囊泡 单核/巨噬细胞 

分 类 号：R563.8[医药卫生—呼吸系统]