冷诱导RNA结合蛋白与炎症反应的研究进展  

Cold-inducible RNA-binding protein and inflammatory response

作　　者：吴宗盛[1] 谢剑锋[1] 邱海波[1] Wu Zongsheng;Xie Jianfeng;Qiu Haibo(Jiangsu Provincial Key Laboratory of Critical Care Medicine,Department of Critical Care Medicine,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]江苏省重症医学重点实验室,东南大学附属中大医院重症医学科,南京210009

出　　处：《中华重症医学电子杂志》2024年第1期42-47,共6页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金重点项目(81930058);国家自然科学基金专项项目(82341032);国家自然科学基金青年项目(82002091)

摘　　要：冷诱导RNA结合蛋白在机体的主要组织器官中广泛表达,是位于细胞核内的RNA伴侣蛋白。近年来研究证实,冷诱导RNA结合蛋白(CIRP)可从损伤的组织细胞中释放至细胞外,作为损伤相关分子模式(DAMPs)与免疫细胞相互作用,参与到级联放大的炎症反应过程。它在脓毒症、急性重症胰腺炎和心肺复苏术后等重症患者外周血中的显著升高与预后不良密切相关。本文就胞外CIRP释放方式及其与靶细胞效应和作用机制作一综述,旨在为开展CIRP相关的研究提供理论依据和参考。Cold-inducible RNA-binding protein(CIRP)is an RNA chaperone protein localized in nucleus and widely expressed in most tissue and organs.In recent years,numerous studies have confirmed that CIRP could be released from injured tissue and cells,interacting with immune cells and being involved in triggering inflammatory response as a damage-associated molecular patterns(DAMPs).In addition,elevation of extracellular CIRP have been found in peripheral blood in septic patients,severe acute pancreatitis patients and post-cardiopulmonary resuscitation patients,associated with poor prognosis.The purpose of this review is to provide a theoretical basis for conducting CIRP relevant research through summarize current knowledge on routes of extracellular CIRP being released,its effects on target cell,and underlying mechanisms.

关 键 词：冷诱导RNA结合蛋白 损伤相关分子模式 炎症反应 免疫细胞 

分 类 号：R392[医药卫生—免疫学]