Targeting the Receptor for Advanced Glycosylation End Products in Inflammation-Associated Diabetes Mellitus  

作　　者：Jieyu Wang Wenbing Mao Yuxiang Yang Fang He Juan Li Hong-Hui Wang Junhua Long 

机构地区：[1]College of Biology,Hunan University,Changsha 410082,China [2]Department of Spine Surgery,The First People’s Hospital of Loudi City,Loudi 417000,China

出　　处：《Journal of Bio-X Research》2024年第4期196-204,共9页生物组学研究杂志(英文)

基　　金：supported by the National Natural Science Foundation of China(No.22177030).

摘　　要：Receptor for advanced glycosylation end products(RAGE)is an essential cell surface receptor that detects advanced glycation end products(AGEs)to mediate important inflammatory and immune processes.Inflammation can cause insulin resistance,in which the excess glucose in the blood that cannot be stored as fat induces hyperglycemia.Under these conditions,AGEs,high mobility group box 1,S100s,and other inflammatory factors induce the production of tumor necrosis factor-α,interleukin-1β,interleukin(interleukin-6),and other proinflammatory cytokines,inducing chronic inflammation.Herein,we reviewed the relationships between diabetes and RAGE-related inflammation and the associated signaling pathways.Recent progress in targeted therapy against RAGE has also been discussed.Since RAGE is involved in the progression of diabetes,it might be a promising therapeutic target for the prevention and management of this disorder and related complications.

关 键 词：receptor advanced glycosylation end products cell surface receptor insulin resistancein inflammatory factors inflammatory immune processesinflammation advanced glycosylation end products rage diabetes mellitus 

分 类 号：R587.1[医药卫生—内分泌]