组织工程骨血管化的构建方法及研究进展  

Approaches in vascularization of tissue-engineered bone and their research progress

作　　者：王玉垒 黎景源 邵能琪 徐文豪 冯凡哲 蔡芝军 余忠政 何晓清 徐永清 崔轶 Wang Yulei;Li Jingyuan;Shao Nengqi;Xu Wenhao;Feng Fanzhe;Cai Zhijun;Yu Zhongzheng;He Xiaoqing;Xu Yongqing;Cui Yi(School of Clinical Medicine,Dali University,Dali 671000,China;Department of Orthopaedic Surgery,The 920th Hospital,Logistics and Support Force of Chinese People's Liberation Army,Kunming 650032,China)

机构地区：[1]大理大学临床医学院,大理671000 [2]中国人民解放军联勤保障部队第九二〇医院骨科,昆明650032

出　　处：《中华创伤骨科杂志》2024年第10期915-920,共6页Chinese Journal of Orthopaedic Trauma

摘　　要：组织工程骨技术以种子细胞、细胞因子和载体支架为基础, 为解决大段骨缺损提供了有效的策略, 在骨缺损修复领域展现出极强的应用潜力。但该技术目前仍面临诸多挑战, 本文重点探讨组织工程骨中的血管化问题, 综述了促进组织工程骨血管化的几种方法, 包括多细胞共培养、生成因子的应用、先进的3D打印技术和外科手术的辅助作用。本文还分析了这些方法的最新研究进展及其局限性, 推测了组织工程骨的未来研究方向。Tissue engineering bone technology,grounded in seed cells,cytokines,and scaffold supports,provides an effective solution for addressing extensive bone defects,demonstrating significant potentials in the field of bone repair.However,this technology still faces numerous challenges.Focusing on vascularization in engineered bones,this article reviews various methods to enhance vascularization within tissue-engineered bones,including multicellular co-culture,application of angiogenic factors,advanced 3D printing,and aid of surgical interventions.This article also analyses the latest research developments and the limitations of the methods,and speculates future research directions for tissue engineered bone.

关 键 词：骨生成 组织工程 血管化 骨缺损 

分 类 号：R318[医药卫生—生物医学工程]