Leonurus japonicus:A promising anticancer Chinese medicine modulating regulated cell death  

作　　者：Xue Li Mingyu Han Huali Fan Sui Li Fu Peng 

机构地区：[1]Department of Pharmacology,Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2025年第3期373-375,共3页中华医学杂志(英文版)

摘　　要：To the Editor:According to the latest statistics published by National Cancer Center of China,approximately 4,824,700 cancer cases were newly diagnosed and 2,574,200 patients died from cancer in China in 2022.[1]Uncontrolled cell proliferation and physiological death resistance,which are the most representative cancer characteristics,complicate the process of restoring health and restrict treatment effectiveness in clinical practice.[2]Regulating multiple cell-death pathways to reprogram cancerous suicide has emerged as a promising approach to achieve valuable drugs discovery.Given the use of Leonurus japonicus as a historical folk medicine,relative hypotoxicity,and malignancy-inhibiting properties,it has shifted scientists’attention to mining its diverse active components and determining its pharmacological activities,thereby paving the way for its administration in clinical cancer treatment.

关 键 词：Leonurus japonicus physiological death resistancewhich drug discovery pharmacological activities reprogram cancerous suicide cell proliferation cancer cell death 

分 类 号：R285[医药卫生—中药学]