短链脂肪酸在肌少症发病机制中的作用  

Research progress on the role of short-chain fatty acids in the pathogenesis of sarcopenia

作　　者：王广宁 李玉杰 高坤范 刘慧松[3] Wang Guangning;Li Yujie;Gao Kunfan;Liu Huisong(Department of Critical Care Medicine,Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Qingdao 266011,China;Reproductive Medicine Center,Women and Children's Hospital,Qingdao University,Qingdao 266000,China;Department of Nuising,Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Qingdao 266011,China)

机构地区：[1]康复大学青岛医院(青岛市市立医院)重症医学科,266011 [2]青岛大学附属妇女儿童医院生殖医学中心,青岛266000 [3]康复大学青岛医院(青岛市市立医院)护理部,266011

出　　处：《中华老年病研究电子杂志》2024年第4期31-37,共7页Chinese Journal of Geriatrics Research(Electronic Edition)

基　　金：青岛市医药卫生科研指导项目(2024-WJKY020)

摘　　要：肌少症是一种与年龄相关的全身骨骼肌退行性疾病,严重影响老年人的生活质量和健康。近年来,肠道菌群与肌少症的相关研究越来越多,其中肠道菌群代谢物短链脂肪酸(SCFA)在肌少症发病中发挥了重要作用。SCFA作为肠道菌群的重要代谢产物,参与肌肉质量和组成、炎症老化和免疫衰老、线粒体功能障碍与氧化应激、胰岛素抵抗、肝脏摄取和代谢、骨骼肌血流代谢等机制,直接或间接对肠道微生物-肌肉轴产生影响。基于SCFA的上述作用,调节饮食和运动方式、补充益生菌和益生元可能可以作为肌少症的干预方式。本文从肠道代谢产物角度,综述SCFA在肌少症发病机制中的潜在作用,以期为SCFA的治疗提供新思路。Sarcopenia is an age-related systemic skeletal muscle degenerative disease that seriously affects the quality of life and health of the elderly.In recent years,there have been an increasing number of studies on the relationship between intestinal flora and sarcopenia.Among them,shortchain fatty acids(SCFA),the metabolites of intestinal flora,play an important role in the pathogenesis of sarcopenia.SCFA are involved in muscle mass and composition,inflammaging aging and immune senescence,mitochondrial dysfunction and oxidative stress,insulin resistance,hepatic uptake and metabolism,and blood flow metabolism in skeletal muscle,which directly or indirectly affect the gut microbe-muscle axis.Based on the aforementioned effects of SCFA,modification of dietary and exercise regimens,and supplementation with probiotics and prebiotics may be able to serve as interventions for sarcopenia.This paper further explore the potential role of SCFA in the pathogenesis of sarcopenia,to provide new ideas for the treatment of sarcopenia.

关 键 词：肌少症 短链脂肪酸 发病机制 疾病干预 

分 类 号：R685[医药卫生—骨科学]