衰老对肌腱的影响  

Effects of senescence on tendons

作　　者：于小鲁 钟章锋 邹德华 陈陟阳 王景浩 周平辉 王华军[1] 郑小飞 Yu Xiaolu;Zhong Zhangfeng;Zou Dehua;Chen Zhiyang;Wang Jinghao;Zhou Pinghui;Wang Huajun;Zheng Xiaofei(Department of Sports Medicine,the First Affiliated Hospital of Ji'nan University,Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine,Guangdong Provincial Key Laboratory of Speed Capability Research,Guangzhou 510630,China;State Key Laboratory of Quality Research in Traditional Chinese Medicines,Faculty of Chinese Medicine,Macao University of Science and Technology,999078 Macao,China;Key Laboratory of Regenerative Medicine of Ministry of Education,Institute of Aging and Regenerative Medicine,Ji'nan University,Guangzhou 510632,China;Department of Pharmacy,the First Affiliated Hospital of Ji'nan University,State Key Laboratory of Frigid Zone Cardiovascular Diseases,Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases,Guangzhou 510630,China;Department of Orthopedics,the First Affiliated Hospital of Bengbu Medical University,Anhui Province Key Laboratory of Tissue Transplantation,Bengbu Medical University,Bengbu 233030,China)

机构地区：[1]暨南大学附属第一医院运动医学科,广州市精准骨科与再生医学重点实验室,广东省速度能力研究重点实验室,广州510630 [2]澳门科技大学中药质量研究国家重点实验室,澳门科技大学中医药学院,中国澳门999078 [3]暨南大学教育部再生医学重点实验室衰老与再生医学研究院,广州510632 [4]暨南大学附属第一医院药学部寒地心血管病全国重点实验室,广州市慢病基础研究与转化重点实验室,广州510630 [5]蚌埠医科大学第一附属医院骨科,蚌埠医科大学组织移植安徽省重点实验室,蚌埠233030

出　　处：《中华老年病研究电子杂志》2024年第3期38-44,共7页Chinese Journal of Geriatrics Research(Electronic Edition)

基　　金：广州市科技计划项目(2024A03J0971、2023A03J0566、2023A03J1015、2024A04J4173、202201020566);国家自然科学基金项目(82074511、82374558、81973660);广东省医学科学技术研究基金项目(A2023143);暨南大学医学联合基金资金资助(YXJC2022005);暨南大学第一临床医学院临床研究项目(2018009);广东省速度能力研究重点实验室开放基金资助项目(2023B1212010009)

摘　　要：随着社会老龄化程度的不断加重,衰老对肌腱的影响备受关注。目前,衰老相关致病机制尚未完全阐明。本文总结了衰老对肌腱细胞、肌腱干细胞及细胞外基质等方面的影响,并探讨了衰老相关肩袖损伤、跟腱断裂等疾病的流行病学特征和衰老肌腱潜在的改善及治疗方法,旨在为进一步研究衰老肌腱相关病理生理机制、开发有效干预策略以及相关疾病治疗提供新思路。As the aging population in China continues to increase,the effect of senescence on tendons has attracted much attention.At present,the pathogenic mechanisms of senescence have not been fully elucidated.This article summarizes the effects of senescence on tendon cells,tendon stem cells,and extracellular matrix,and discusses the epidemiological characteristics of senescence-related diseases such as rotator cuff injury and Achilles tendon rupture,as well as potential ameliorations and treatments for senescence tendons.The aim is to provide new ideas for further research into the pathological and physiological mechanisms of senescence tendons,the development of effective intervention strategies,and the treatment of related diseases.

关 键 词：肌腱 干细胞 衰老 运动医学 

分 类 号：R687.2[医药卫生—骨科学] R685[医药卫生—外科学]