男性2型糖尿病患者空腹C肽和定量胰岛素敏感性检测指数与血浆致动脉粥样硬化指数的相关性  

Association of fasting c-peptide and quantitative insulin sensitivity index with arteriosclerosis index of plasma in male patients with T2DM

作　　者：吴晓明[1] 翟仰魁 王娟[1] 张硕 许杰 潘从清[1] Wu Xiaoming;Zhai Yangkui;Wang Juan;Zhang Shuo;Xu Jie;Pan Congqing(Department of Integrated Chinese and Western medicine,NHC Key Laboratory of Hormones and Development(Tianjin Medical University),Tianjin Key Laboratory of Metabolic Diseases,Tianjin Medical University Chu Hsien-I Memorial Hospital&Tianjin Institute of Endocrinology,Tianjin 300134,China)

机构地区：[1]天津医科大学朱宪彝纪念医院、天津市内分泌研究所、国家卫健委激素与发育重点实验室、天津市代谢性疾病重点实验室,天津300134

出　　处：《中华肥胖与代谢病电子杂志》2024年第4期288-294,共7页Chinese Journal Of Obesity and Metabolic Diseases:Electronic Edition

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-032A)

摘　　要：目的筛选口服葡萄糖耐量实验(OGTT)评估参数中男性2型糖尿病(T2DM)患者动脉粥样硬化风险的最佳预测因子。方法横断面研究方法观察171例2019年10月至2023年10月在天津医科大学朱宪彝纪念医院住院的男性T2DM患者,根据致动脉粥样硬化指数(AIP)分为致动脉粥样硬化表型组(A组:AIP≥0.06)和非致动脉粥样硬化表型组(N组:AIP<0.06)。所有患者接受OGTT,计算稳态模型胰岛素抵抗指数(HOMA-IR)、β细胞功能指数(HOMA-β)、胰岛素作用指数(IAI)、定量胰岛素敏感性指数(QUICKI)、C肽胰岛素抵抗指数(HOMA IR-CP)和适用于糖尿病患者的C肽胰岛功能指数(HOMA islet-CP DM)。结果A组空腹C肽、口服75 g葡萄糖后60 min和120 min的C肽值、ln(HOMAIR)、ln(HOMA-β)、ln(HOMA IR-CP)和ln(HOMA islet-CP DM)较N组高(P<0.05),IAI和QUICKI较N组低(P<0.05)。AIP与各时间点的C肽值、ln(HOMA-IR)、ln(HOMA-β)、ln(HOMA-IR CP)和ln(HOMA islet-CP-DM)正相关(P<0.001),与IAI和QUICKI负相关(P<0.001)。多元线性回归分析表明,空腹C肽和QUICKI是AIP的独立影响因子。结论空腹C肽和QUICKI是男性T2DM患者AIP的独立预测因素,值得临床医生关注。Objective To identify the factors that best predict the risk of atherosclerosis in male patients with type 2 diabetes mellitus(T2DM)from the parameters evaluated by the oral glucose tolerance test(OGTT).Methods A total of 171 hospitalized male patients with T2DM in Tianjin Medical University Chu Hsien-I Memorial Hospital from October 2019 to October 2023 were divided into atherogenic phenotype group(group A,AIP≥0.06)and non-atherogenic phenotype group(group N,AIP<0.06).The patients were accepted OGTT.The homeostasis model insulin resistance index(HOMA-IR),insulin secretion index(HOMA-β),insulin action index(IAI),quantitative insulin sensitivity check index(QUICKI),C peptide insulin resistance index(HOMA IR-CP)and C-peptide islet function index suitable for diabetes patients(HOMA islet-CP DM)were calculated according to OGTT results.Results Fasting C-peptide,C-peptide values at 60 min and 120min after oral administration of 75g glucose,ln(HOMA-IR),ln(HOMA-β),ln(HOMA IR-CP)and ln(HOMA islet-CP DM)in Group A were higher than those in group N(P<0.05),while IAI and QUICKI were lower than those in group N(P<0.05).AIP was positively correlated with C-peptide values at different times,ln(HOMA-IR),ln(HOMA-β),Ln(HOMA-IR-CP)and ln(HOMA islet CP-DM)(P<0.001),while negatively correlated with IAI and QUICKI(P<0.001).Multiple linear regression analysis showed that fasting C-peptide and QUICKI were independent influencing factors of AIP.Conclusions Fasting C-peptide and QUICKI are independent predictors of AIP in male patients with type 2 diabetes,which deserves clinicians&apos;attention.

关 键 词：C肽 定量胰岛素敏感性检测指数 动脉粥样硬化 男性 2型糖尿病 口服葡萄糖耐量实验 

分 类 号：R587.1[医药卫生—内分泌]