布鲁氏病菌临床实验室诊断技术应用研究进展  

Progress in applied laboratory diagnostic techniques for brucellosis

作　　者：付薪静 穆耶赛尔·艾尼娃尔 赵帆 胡守奎 Fu Xinjing;Mu Yesaier·Ainiwaer;Zhao Fan;Hu Shoukui(Department of Laboratory Medicine,The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Department of Laboratory Medicine,Shougang Hospital of Peking University,Beijing 100144,China;Department of Laboratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)

机构地区：[1]新疆医科大学第二附属医院检验科,乌鲁木齐830011 [2]北京大学首钢医院检验科,北京100144 [3]郑州大学附属郑州中心医院检验科,郑州450007

出　　处：《中华临床医师杂志(电子版)》2024年第10期949-954,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：首都卫生发展科研专项基金(2022-2-6042)

摘　　要：布鲁氏病菌是由布鲁氏菌引起的急性或慢性人畜共患传染病。该病属自然疫源性疾病,传染性强,且在世界各地分布广泛。全世界每年报道布病的病例超过50万例,严重威胁着人们的生命健康。世界上每年因该病造成的直接经济损失逾30亿美元。鉴于布病的巨大危害性,且存在临床不典型性、无特异性、极易复发等特征,及时开展灵敏、准确及具有特异性的实验室检测对于该病的诊断尤为迫切和重要。本文对现有实验室常用诊断方法及近年来随着分子生物学及生信技术发展而新兴的诊断方法进行综述,以期为布病的实验室诊断提供理论参考和技术支撑。Brucellosis is an acute or chronic zoonotic infectious disease caused by Brucella.This disease is a natural focal disease with strong infectivity and is widely distributed around the world.More than 500000 cases of brucellosis are reported worldwide every year,seriously threatening people's lives and health.The direct economic loss caused by this disease exceeds 3 billion US dollars every year.In view of the great harmfulness of brucellosis and its characteristics of lack of typical clinical symptoms,non-specificity,and easy recurrence,timely carrying out sensitive,accurate,and specific laboratory tests is particularly urgent and important for the diagnosis of this disease.This paper reviews the common diagnostic methods used in existing laboratories and the emerging diagnostic methods with the development of biomolecular biology and bioinformatics technology in recent years,in order to provide theoretical reference and technical support for the laboratory diagnosis of brucellosis.

关 键 词：布鲁氏菌病 血清学检查 细菌学检查 分子生物学检查 

分 类 号：R516.7[医药卫生—内科学]