从PVAT白色脂肪棕色化角度探讨中药在防治动脉粥样硬化中的应用  

Discussion of application of traditional Chinese medicine in atherosclerosis from the perspective of browning of white adipose tissue

作　　者：石佳娜 钱琳艳[2,3] 姬凯悦 祁金文 胡情[1,3] 孙佳斌 Shi Jiana;Qian Linyan;Ji Kaiyue;Qi Jinwen;Hu Qing;Sun Jiabin(Department of Pharmacy,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou 310014,China;Department of Cardiovascular Medicine,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou 310014,China;Hangzhou Medical College,Hangzhou 310014,China;Department of Pharmacy,Deqing People's Hospital,Huzhou 313200,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)药学部,杭州310014 [2]浙江省人民医院(杭州医学院附属人民医院)心血管内科,杭州310014 [3]杭州医学院,杭州310014 [4]德清县人民医院药学部,浙江湖州313200

出　　处：《中华临床医师杂志(电子版)》2024年第9期853-858,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：浙江省基础公益研究项目(LGF22H280012);浙江省中医药科技计划项目(2022ZB037);浙江省中西医结合学会临床药学科研基金(2019LY017);浙江省药学会医院药学专项科研资助项目(2018ZYY11)

摘　　要：动脉粥样硬化是一种慢性动脉炎症性疾病,其特征为脂质、炎症和内皮功能障碍的积累,是导致糖尿病、冠心病等代谢性疾病的主要病因之一。其发病机制复杂多变,迄今尚未阐明。研究发现在肥胖、炎症等病理状态下,血管周围脂肪组织会通过脂肪细胞表型转化进而释放脂肪因子及炎症因子并调节各类炎症细胞,“由外而内”调控动脉粥样硬化进程。研究发现中药可以通过调节血管周围脂肪结构比例与功能,具有防治动脉粥样硬化的作用。本文综述单味中药、中药单体及中药复方通过调控血管周围脂肪白色脂肪棕色化来防治动脉粥样硬化的作用机制,以期为临床治疗提供新方法新思路。Atherosclerosis is a chronic inflammatory arterial disease characterized by the accumulation of lipids,inflammation,and endothelial dysfunction,and it is one of the main causes of metabolic diseases such as diabetes and coronary heart disease.Its pathogenesis is complex and variable,and has not yet been fully elucidated.Research has found that under pathological conditions such as obesity and inflammation,perivascular adipose tissue undergoes adipocyte phenotypic transformation,leading to the release of adipokines and inflammatory cytokines,and regulates various inflammatory cells,thereby regulating the progression of atherosclerosis"from outside to inside".Studies have found that traditional Chinese medicine can prevent and treat atherosclerosis by regulating the proportion and function of perivascular adipose tissue.This article reviews the mechanism of action of single Chinese herbs,single herb constituents,and Chinese herbal formulas in preventing and treating atherosclerosis by regulating the browning of perivascular adipose tissue,aiming to provide new methods and ideas for clinical treatment.

关 键 词：动脉粥样硬化 血管周围脂肪 中药 白色脂肪棕色化 

分 类 号：R259[医药卫生—中西医结合]