Design and implementation of a multicenter protocol to obtain impulse oscillometry data in preterm children  

作　　者：Katharine Tsukahara Clement L.Ren Julian Allen Carla Bann Joseph McDonough Kristina Ziolkowski Charles C.Clem Sara B.DeMauro 

机构地区：[1]Division of Pulmonary and Sleep Medicine,Department of Pediatrics,Children’s Hospital of Philadelphia,Philadelphia,Pennsylvania,USA [2]Division of Statistical and Data Sciences,RTI International,Research Triangle Park,North Carolina,USA [3]Division of Neonatology,Department of Pediatrics,Children’s Hospital of Philadelphia,Philadelphia,Pennsylvania,USA [4]Section of Pediatric Pulmonology,Allergy,and Sleep Medicine,Department of Pediatrics,Indiana University School of Medicine,Indianapolis,Indiana,USA [5]Department of Pediatrics,Division of Pediatric Pulmonary and Sleep Medicine,University of Utah,Salt Lake City,UT,USA

出　　处：《Pediatric Investigation》2024年第4期253-264,共12页儿科学研究(英文)

基　　金：National Heart,Lung,and Blood Institute,Grant/Award Numbers:U24HL137729,U24HL143216,UG3HL143204,UH3HL137872,UH3HL137872-04S1;Eunice Kennedy Shriver National Institute of Child Health and Human Development,Grant/Award Numbers:UG1HD21373,UG1HD27853,UG1HD27856,UG1HD36790,UG1HD68244,UG1HD68284,UG1HD68244;Children’s Hospital of Philadelphia,Grant/Award Number:Morse Asthma Research Fund;The Capek Foundation;National Human Genome Research Institute,Grant/Award Number:T32 HG009495

摘　　要：Importance:Objective measures of lung function are critical for assessing respiratory outcomes of prematurity.Among extremely low gestational age neonates(ELGANs)(<29 weeks gestational age),high rates of neurodevelopmental impairment may interfere with lung function testing.Impulse oscillometry(IOS)is a noninvasive test of respiratory system mechanics not requiring forced expiration.Objective:To describe a multicenter study design for respiratory follow-up testing in a cohort with a high rate of extreme prematurity.Methods:School-age children enrolled in two prior trials of ELGANs and term controls were assessed by IOS at five centers.Groups consisted of children with prematurity with a high incidence of bronchopulmonary dysplasia,children with prematurity with no or minimal lung disease,and healthy term children.A rigorous centralized review process reviewed IOS studies for technical acceptability.Approach to design and implementation,rates of feasibility and success,and characteristics of participants are described.Results:A total of 243 children were recruited,of whom 239(98%)attempted oscillometry.There were high rates of technical acceptability across all three cohorts(85%–90%of attempted tests),and across all five centers(80%–94%of attempted tests).Respiratory and neuromotor clinical factors associated with testing failure included a higher number of days on ventilation during neonatal intensive care,a history of intraventricular hemorrhage grade 3 or 4,and gross motor functional impairment.Interpretation:We report high rates of feasibility and success of oscillometry in a large multicenter ELGAN population,in whom neurological and developmental comorbidities likely play a confounding role.

关 键 词：Bronchopulmonary dysplasia Extremely low gestational age neonates Extremely preterm infants OSCILLOMETRY Pulmonary function tests 

分 类 号：R722.6[医药卫生—儿科]