Bird's eye view of natural products for the development of new anti-HIV agents:Understanding from a therapeutic viewpoint  

作　　者：Md.Al Amin Mohamed H.Nafady Mehrukh Zehravi Sherouk Hussein Sweilam Kusuma Praveen Kumar M.Akiful Haque Aziz Unnisa Laliteshwar Pratap Singh Mohammed Sayeed Mohammed Ali Alshehri Irfan Ahmad Talha Bin Emran Md.Zia Uddin 

机构地区：[1]Department of Pharmacy,Faculty of Health and Life Sciences,Daffodil International University,Dhaka,Bangladesh [2]Faculty of Applied Health Science Technology,Misr University for Science and Technology,Giza,Egypt [3]Department of Clinical Pharmacy,College of Dentistry&Pharmacy,Buraydah Private Colleges,Buraydah,Saudi Arabia [4]Department of Pharmacognosy,Faculty of Pharmacy,Egyptian Russian University,Badr,Egypt [5]Department of Clinical Pharmacy Girls Section,Prince Sattam Bin Abdul Aziz University,Al-Kharj,Saudi Arabia [6]Department of Pharmaceutical Chemistry,School of Pharmaceutical Sciences,Delhi Pharmaceutical Sciences and Research University(DPSRU),Govt.of N.C.T.of Delhi,New Delhi,India [7]Department of Pharmaceutical Analysis,School of Pharmacy,Anurag University,Hyderabad,India [8]Department of Pharmaceutical Chemistry,College of Pharmacy,University of Ha'il,Ha'il,Saudi Arabia [9]Department of Pharmaceutical Chemistry,Narayan Institute of Pharmacy,Gopal Narayan Singh University,Sasaram(Rohtas),Bihar,India [10]Department of Pharmacology,School of Pharmacy,Anurag University,Hyderabad,Telangana,India [11]Department of Biology,Faculty of Science,University of Tabuk,Tabuk,Saudi Arabia [12]Department of Clinical Laboratory Sciences,College of Applied Medical Science,King Khalid University,Abha,Saudi Arabia [13]Department of Pharmacy,Faculty of Pharmaceutical Sciences,University of Science and Technology Chittagong,Chattogram,Bangladesh

出　　处：《Animal Models and Experimental Medicine》2025年第3期441-457,共17页动物模型与实验医学(英文)

基　　金：funding this work through the Large Research Group Project under grant number RGP.02/513/45.

摘　　要：Acquired immune deficiency syndrome(AIDS)is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system.The primary effect of HIV is to decrease host immunity,exposing the host to external pathogens.The development of pharmaceutical drugs that directly cure the infection is crucial because of the current wide-ranging epidemic of HIV.Most therapeutic anti-HIV drugs are nucleosides.However,their high toxicity and potential for drug resistance restrict their use.Many of the most effective clinical drugs used to inhibit HIV,the activation of latent HIV,and AIDS have been obtained from natural sources.This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.Notwithstanding,further clinical research studies are needed to understand the subject and its dynamics.

关 键 词：AIDS anti-HIV agents HIV immune system marine compounds natural products PHYTOCONSTITUENTS 

分 类 号：R51[医药卫生—内科学]