A comparative study of the established methods and evaluation of rat trauma models  

作　　者：Zhenmin Sun Jia Sun Gang Su Ruohan Wang Zhaohui Zhai Feng Yu Yuli Li 

机构地区：[1]Qingdao Hospital,University of Health and Rehabilitation Sciences,Qingdao Municipal Hospital,Qingdao,China [2]Shandong Second Medical University,Weifang,China [3]State Key Laboratory of Marine Resource Utilization in South China Sea,Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources,College of Materials Science and Engineering,Hainan University,Haikou,China

出　　处：《Animal Models and Experimental Medicine》2025年第3期501-510,共10页动物模型与实验医学(英文)

基　　金：Shandong Provincial Natural Science Foundation,Grant/Award Number:ZR2022MH211;the Key Program of Shandong Provincial Natural Science Foundation,Grant/Award Number:ZR2020KE018;National Natural Science Foundation of China,Grant/Award Number:52003068。

摘　　要：Background:Scientific animal models are indispensable for studying trauma repair.This work aimed at establishing a more scientific rat trauma model by studying different rat trauma models caused by different trauma numbers,locations,and trauma attachment tension unloaders and rat age.Methods:A four-trauma self-upper,lower,left and right control model;a two-trauma self-trauma bare and ring control model;and a young and old rat trauma model were created to evaluate the condition of these traumas.Results:In the four-trauma self-control model,the healing status of the upper proximal cephalic trauma was better than that of the lower proximal caudal trauma,whereas there was no significant difference between the left and right trauma.The healing rate and postwound condition of the trauma with a ring control in the two-trauma model were better than those of the bare side.The healing speed of the old rats was slower,and the amount of extracellular matrix in the subcutaneous tissue after healing was significantly lower than that of the young rats.Conclusion:The double trauma with a ring is a more scientific and reasonable experimental model.There is a significant difference between young and old rats in the wound healing process.Therefore,the appropriate age of the rats should be selected according to the main age range of the patients with similar conditions in the clinical setting being mimicked.

关 键 词：age of the rats healing speed modeling rat trauma skin tension unloader 

分 类 号：R68[医药卫生—骨科学]