痛风患者冠状动脉钙化与尿酸盐结晶情况及冠状动脉钙化的危险因素分析  

Spectral CT coronary artery calcification score and urate crystals and risk factors for coronary artery calcification in gout patients

作　　者：张丽红 徐双月 王英 ZHANG Lihong;XU Shuangyue;WANG Ying(Department of Radiology,Lishui People's Hospital,Lishui 323000,China)

机构地区：[1]丽水市人民医院放射科,浙江丽水323000

出　　处：《全科医学临床与教育》2025年第3期211-214,共4页Clinical Education of General Practice

摘　　要：目的 分析痛风患者的光谱CT冠状动脉钙化与尿酸盐结晶情况及冠状动脉钙化的危险因素。方法 选取126例痛风患者,依据临床分期分为A组(急性期痛风患者)与B组(间歇期及慢性期痛风患者),每组各63例。比较两组冠状动脉钙化、尿酸盐结晶情况。根据是否发生冠状动脉钙化,将患者分为冠状动脉钙化组与无冠状动脉钙化组,用logistic回归分析痛风患者发生冠状动脉钙化的独立危险因素。结果 B组总冠状动脉钙化率高于A组(χ^(2)=4.78,P<0.05)。B组双足、双踝、双膝尿酸盐结晶及尿酸盐结晶总数均高于A组(t分别=3.78、6.41、7.19、9.45,P均<0.05)。痛风分期、年龄、体重指数、尿酸盐结晶数量均是痛风患者发生冠状动脉钙化的独立危险因素(OR分别=5.95、1.59、1.42、2.04,P均<0.05)。结论 间歇期及慢性期痛风患者发生冠状动脉钙化的风险比急性期痛风患者高,且体内存在更多的尿酸盐结晶。间歇期及慢性期痛风、年龄大、体重指数高、尿酸盐结晶数量多均会增加痛风患者发生冠状动脉钙化的风险。Objective To explore the spectral CT coronary artery calcification score and urate crystals,and analyze the risk factors for coronary artery calcification in gout patients.Methods Totally 126 gout patients were selected and divided into group A(acute gout patients)and group B(intermittent and chronic gout patients)based on clinical staging,with 63 patients in each group.The differences of coronary artery calcification score and urate crystals between the two groups were compared.According to the occurrence of coronary artery calcification,the patients were divided into coronary artery calcification group and non-coronary artery calcification group.The basic data of the two groups were compared,and the independent risk factors of coronary artery calcification in gout patients were analyzed by logistic regression.Results The total coronary artery calcification rate in group B was higher than that in group A (χ^(2)=4.78,P<0.05).The amount of urate crystals in both feet,ankles,and knees of group B were higher than that of group A as well as total amount of uratecrystals(t=3.78,6.41,7.19,9.45,P<0.05).Gout staging,age,body mass index,and the number of urate crystals were independent risk factors for coronary artery calcification in gout patients(OR=5.95,1.59,1.42,2.04,P<0.05).Conclusion The danger of coronary artery calcification is higher in patients with intermittent and chronic gout than in patients with acute gout,and there are more urate crystals in the body.Intermittent and chronic gout,older age,higher body mass index,and higher quantity of urate crystals all increase the risk of coronary artery calcification.

关 键 词：痛风 光谱CT 冠状动脉钙化积分 尿酸盐结晶 

分 类 号：R58[医药卫生—内分泌]