谷精草中12种金属元素测定及健康风险评估  

Determination and Health Risk Assessment in Eriocaulon Buergerianum Koern

作　　者：林嘉敏 梁锦晖 李红艳 邓丽华 曾仕久 赵静 刘啟明 Lin Jiamin;Liang Jinhui;Li Hongyan;Deng Lihua;Zeng Shijiu;Zhao Jing;Liu Qiming(Zhaoqing Institute for Drug Control,Zhaoqing 526000,China)

机构地区：[1]肇庆市药品检验所,广东肇庆526000

出　　处：《实验与分析》2025年第1期39-43,共5页LABOR PRAXIS

摘　　要：为了解中药饮片谷精草中12种金属元素的污染残留情况,评价其对人体健康的风险。文章利用先进的ICPMS分析技术,对收集到的15批谷精草样本中的Pb、Hg、Cd、Cu、As、Cr、Ba、Co、Ni、V、Tl、Mn等金属元素进行了定量分析。通过Monte Carlo模拟技术,深入探讨了谷精草的两种不同用药方式,并运用靶标危害系数法(THQ)与综合危害指数法(HI)两种评估手段,对金属元素可能引发的人类健康非致癌风险进行了全面评估。结果表明谷精草样品中除了Hg大部分未检出外,其他金属元素均有检出。非致癌健康风险评估结果显示谷精草在原粉入药情形下THQTl的P95分位值、P50分位值均>1,总危害指数HI显示谷精草对所有暴露人群均具有非致癌性风险。而在水煎煮入药情形下,THQTl仅有P95分位值>1。谷精草中Tl元素存在非致癌风险,中药中Tl元素对人体健康的危害需引起人们关注。To understand the contamination and residue of 12 metal elements in the traditional Chinese medicine(TCM)Eriocaulon buergerianum Koern and evaluate the risks to human health.ICP-MS was used to detect the contents of Pb,Hg,Cd,Cu,As,Cr,Ba,Co,Ni,V,Tl,and Mn in 15 batches of Eriocaulon buergerianum Koern.Using Monte Carlo simulation technology,considering two different medication methods,the non-carcinogenic health risks of Pb,Cd,Cu,As,Cr,Ba,Co,Ni,V,Tl,and Mn to humans were assessed according to the Target Hazard Quotient(THQ)method and the Hazard Index(HI)method.Except for Hg,which was mostly undetected in the Eriocaulon buergerianum samples,all other metal elements were detected.The non-carcinogenic health risk assessment results showed that under the condition of using the raw powder for medication,both the P95 and P50 percentile values of THQ for Tl were>1,and the total Hazard Index(HI)indicated that Eriocaulon buergerianum poses a non-carcinogenic risk to all exposed populations.In the case of decoction with water,only the P95 percentile value of THQ for Tl was>1.There is a non-carcinogenic risk associated with the Tl element in Eriocaulon buergerianum,and the harm of the Tl element in TCM to human health needs to be brought to attention.

关 键 词：谷精草 金属元素 蒙特卡洛 健康风险 

分 类 号：R917[医药卫生—药物分析学]