Research progress on integrated traditional Chinese and western medicine in the treatment of diabetic kidney disease  

中西医结合治疗糖尿病肾病的研究进展

作　　者：Luo Yadan Yang Yuqi Zha Yan 罗亚丹;杨宇齐;查艳(遵义市第一人民医院,遵义医科大学第三附属医院肾内科,贵州遵义563000;国家卫生健康委员会肺脏免疫性疾病诊治重点实验室,贵州省常见慢性疾病发病机制及防治研究全省重点实验室,贵州省人民医院肾内科,贵州贵阳550002)

机构地区：[1]Department of Nephrology,the First People’s Hospital of Zunyi and the Third Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,China [2]Department of Nephrology,NHC Key Laboratory of Pulmonary Immunological Disease,Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases Research,Guizhou Provincial People’s Hospital,Guiyang Guizhou 550002,China

出　　处：《遵义医科大学学报》2025年第3期295-306,共12页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:82360148);贵州省科学技术基金资助项目[NO:贵州省科技基金-ZK(2024)一般679];遵义市科技合作项目[NO:HZ(2022)94]。

摘　　要：Objective Diabetic kidney disease is a serious complication of diabetes,which is the leading cause of end-stage renal disease worldwide.Approximately 40%of individuals with diabetes develop diabetic kidney disease.At present,the most important drugs for diabetic kidney disease include renin-angiotensin-aldosterone system inhibitors,angiotensin receptor blockers,sodium-glucose cotransporter-2 inhibitors,and newly approved aldosterone receptor antagonists.However,to date,there are still no effective drugs to prevent diabetic kidney disease from progressing to end-stage renal disease.Network pharmacology combined with bioinformatics and pharmacology provides a powerful tool for studying the mechanism of drug action.Traditional Chinese medicine has accumulated rich experience in the treatment of diabetic kidney disease,and its multi-target,multi-component,and multi-pathway characteristics provide new ideas for modern medicine.This article reviews the research progress of network pharmacology and drug therapy in diabetic kidney disease.糖尿病肾病是糖尿病严重并发症。全球终末期肾病的主要病因为糖尿病肾病,在糖尿病人群中约40%进展为糖尿病肾病。目前,糖尿病肾病主要的治疗药物有肾素-血管紧张素-醛固酮系统抑制剂、血管紧张素受体阻滞剂、钠-葡萄糖共转运蛋白-2抑制剂和最新批准的醛固酮受体拮抗剂,但迄今为止,仍没有效的药物阻止糖尿病肾病进展为终末期肾病。网络药理学结合生物信息学与药理学,为研究药物作用机制提供了有力工具。中医药在治疗方面积累了丰富经验,其多靶点、多组分、多通路的特点为现代医学提供了新的思路。现就网络药理学及药物治疗在糖尿病肾病中的研究进展作一综述。

关 键 词：diabetic kidney disease network pharmacology traditional Chinese medicine end-stage renal disease 

分 类 号：R692.5[医药卫生—泌尿科学]