Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy  

作　　者：Zi-Jia Liu Xian Xu Ya-Nan Lyu Dong-Li Li Hao Zhou Yuan-Yuan Gong 

机构地区：[1]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [2]National Clinical Research Center for Eye Diseases,Shanghai 200080,China [3]Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai 200080,China [4]Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai 200080,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第4期663-671,共9页国际眼科杂志(英文版)

基　　金：Supported by the National Key R&D Program of China(No.2016YFC0904800,No.2019YFC0840607);the National Science and Technology Major Project of China(No.2017ZX09304010);the Clinical Research Innovation Plan of Shanghai General Hospital(No.CTCCR-2018BP04).

摘　　要：AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients with acute NAION(<30d of visual acuity loss)were enrolled and given intravitreal TA(IVTA)once.Visual field(VF),best corrected visual acuity(BCVA),retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)thickness,radial peripapillary capillary(RPC)density,and intraocular pressure(IOP)were evaluated at baseline and 7d,1,3,and 6mo after IVTA.RESULTS:VF and BCVA were significant improved during the follow-up according to the mean deviation(MD),visual field index(VFI),and Early Treatment Diabetic Retinopathy Study(ETDRS)scores(all P<0.001).There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset.The RNFL thickness,GCC thickness and RPC density were significantly decreased(all P<0.001).Temporary ocular hypertension was present in five eyes.CONCLUSION:Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage.However,optic nerve atrophy still existed.

关 键 词：nonarteritic anterior ischemic optic neuropathy triamcinolone acetonide intravitreal injections visual field visual acuity 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]