Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents:a Metaanalysis  

作　　者：Hao-Bo Fan Zhi-Lin Li Xue-Min Zhang Ai-Rui Xie Qiu-Mei Wei Ting-Ting Song Jun-Guo Duan 

机构地区：[1]Eye College of Chengdu University of Traditional Chinese Medicine,Chengdu 610000,Sichuan Province,China [2]Department of Optometry and Pediatric Ophthalmology,Ineye Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610000,Sichuan Province,China [3]Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with TCM Laboratory,Chengdu 610000,Sichuan Province,China [4]Retinal Image Technology and Chronic Vascular Disease Prevention&Control and Collaborative Innovation Center,Chengdu 610000,Sichuan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第4期723-734,共12页国际眼科杂志(英文版)

基　　金：Supported by Sichuan Province Science and Technology Plan(No.2023YFS0506);Medical Research Project of Jinniu District,Chengdu,Sichuan Province(No.JNKY2024-94);Xinglin Scholar Program at Chengdu University of Traditional Chinese Medicine(No.ZYTS2023028).

摘　　要：AIM:To evaluate the effects of microlens design of peripheral defocus modifying spectacle lenses(PDMSLs)and non-microlens design of PDMSLs on controlling myopia progression in children and adolescents.METHODS:A systematic search was carried out in the PubMed,Cochrane Library,Embase,CNKI,and Web of Science databases.The search targeted randomized controlled trials(RCTs)and cohort studies(CTs)that explored the effects of PDMSLs on myopia control among children and adolescents.The Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale were employed to evaluate the risk of bias in the included studies.The published biases of the included studies were evaluated using Egger’s test.RESULTS:Nine studies(7 RCTs,2 CTs)were included,involving 4332 participants in the PDMSLs group and 7317 participants in the single vision lenses(SVLs)group.Metaanalysis showed that PDMSLs with microlens design had lower change in spherical equivalent refraction(SER)than SVLs at 6,12,18,and 24mo after wearing glasses,with reductions of 0.19 D(95%CI:0.14 to 0.24,P<0.00001),0.36 D(95%CI:0.25 to 0.46,P<0.00001),0.43 D(95%CI:0.32 to 0.55,P<0.00001),and 0.51 D(95%CI:0.33 to 0.69,P<0.00001),respectively.The changes in axial length(AL)were also lower in PDMSLs compared to SVLs,with reductions of-0.09 mm(95%CI:-0.13 to-0.04,P=0.0002),-0.15 mm(95%CI:-0.21 to-0.08,P<0.00001),-0.27 mm(95%CI:-0.34 to-0.20,P<0.00001),and-0.29 mm(95%CI:-0.38 to-0.20,P<0.00001),respectively.There was no significant difference between the non-microlens group and SVLs in controlling the changes of SER and AL in myopia(both P>0.05).CONCLUSION:The synthesized evidence indicates superior myopia management outcomes with microlens design of PDMSLs compared to both SVLs and nonmicrolens design of PDMSLs in children and adolescents.

关 键 词：peripheral defocus spectacle lenses MYOPIA axial length META-ANALYSIS 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]