孤独症中不同大脑活动相关的基因表达变化  

Altered gene expression associated with different brain activities in autism spectrum disorder

作　　者：翁玉悦 翁旭初 耿红岩 WENG Yuyue;WENG Xuchu;GENG Hongyan(Institute of Brain Research and Rehabilitation,South China Normal University,Guangzhou 510898,China)

机构地区：[1]华南师范大学脑科学与康复医学研究院,广州510898

出　　处：《心理科学进展》2025年第4期574-587,共14页Advances in Psychological Science

基　　金：国家社会科学基金重大项目(20&ZD296);广东省重点领域研发计划资助(2019B030335001);国家自然科学基金青年项目(32200815);中国博士后科学基金(2022M721218)。

摘　　要：大脑活动受到基因表达的调控,基因表达的变化可以反映大脑活动状态的改变。随着脑成像基因组学的发展,结合跨皮质区域的功能磁共振成像和转录组分析,目前已经能够检测到与大脑结构和功能相关的基因组变化。这方面的研究正逐步应用于神经精神疾病领域,包括孤独症谱系障碍(Autism Spectrum Disorders,ASD)中,以探究基因表达与大脑活动的关系。对与大脑活动相关的基因在ASD发病中的作用机制进行研究,可以为ASD脑活动变化分析、发病机制探究和临床治疗对策开发提供生理功能参考依据。Brain activity is regulated by gene expression,and altered gene expression can reflect the transformed brain state.With the development of brain imaging genomics,it is now possible to detect genomic changes associated with brain structure and function,combined with the functional magnetic resonance imaging(fMRI)and transcriptome analysis across cortical regions.At present,this research approach has been gradually applied to neuropsychiatric diseases,including autism spectrum disorders(ASD),to explore the relationship between gene expression and brain activity.The study of the mechanism of genes related to brain activity in the pathogenesis of ASD can provide physiological reference for the analysis of brain activity changes,the exploration of pathogenesis and the development of clinical treatment strategies of ASD patients.

关 键 词：孤独症 脑成像 大脑活动 基因表达 

分 类 号：B845[哲学宗教—心理学]