炎症性肠病与儿童孤独症谱系障碍的关系  

Relationship between inflammatory bowel disease and autism spectrum disorder in children

作　　者：范桂容 翁旭初 耿红岩 FAN Guirong;WENG Xuchu;GENG Hongyan(Institute of Brain Research and Rehabilitation,South China Normal University,Guangzhou 510898,China)

机构地区：[1]华南师范大学脑科学与康复医学研究院,广州510898

出　　处：《心理科学进展》2025年第4期611-619,共9页Advances in Psychological Science

基　　金：国家社会科学基金重大项目(20&ZD296)。

摘　　要：孤独症谱系障碍(Autism spectrum disorder,ASD)是一类神经发育障碍疾病,除了社交障碍、重复刻板行为等核心症状外,几乎一半的ASD患者出现了胃肠道症状,表现出炎症性肠病(inflammatory bowel disease,IBD)。IBD是一种与免疫失调、肠道微生物组改变、微量营养吸收不良和贫血相关的慢性疾病,这些特征可能是ASD相关的围产期因素。患有ASD的儿童很可能被诊断出患有包括IBD在内的共生疾病。通过治疗IBD来缓解或干预儿童ASD的治疗方式已经初见成效,未来可以开展更多临床实验来证实IBD治疗的有效性和安全性。对IBD与ASD、父母IBD和儿童ASD之间关系的探究可以为儿童ASD的病因研究、早期筛查及临床治疗提供进一步的证据支持。Autism spectrum disorder(ASD)is a neurodevelopmental condition.In addition to core symptoms including social impairments and restricted repetitive behaviors,about half of individuals with ASD also experience gastrointestinal symptoms and inflammatory bowel disease(IBD).IBD is a kind of chronic disease associated with immune dysregulation,gut microbiome alterations,micronutrient malabsorption and anaemia,which may be perinatal factors associated with ASD.It's likely that comorbidities such as IBD are diagnosed in children with ASD.Although there has been some initial success in treating IBD to reduce or prevent ASD in children,further clinical trials should be carried out in the future to verify the effectiveness and safety of IBD treatment.Additional evidence to support aetiological research,early diagnosis,and clinical management of ASD in children might result from examining the association between IBD and ASD,as well as the relationship between parental IBD and childhood ASD.

关 键 词：孤独症谱系障碍 炎症性肠病 克罗恩病 溃疡性结肠炎 

分 类 号：B845[哲学宗教—心理学]