宫颈病变合并高危型人乳头状瘤病毒持续性感染患者外周血Th1/Th2平衡状况及临床意义  

Peripheral blood Th1/Th2 balance and its clinical significance in patients with cervical lesions and persistent high-risk human papillomavirus infection

作　　者：王豫平 袁晓敏 WANG Yu-ping;YUAN Xiao-min(Department of Obstetrics and Gynecology,Nanyang Traditional Chinese Medicine Hospital,Nanyang 473000,Henan,CHINA)

机构地区：[1]南阳市中医院妇产科,河南南阳473000

出　　处：《海南医学》2025年第6期822-826,共5页Hainan Medical Journal

基　　金：2023年度河南省南阳市科技发展计划项目(编号:24KJGG134)。

摘　　要：目的探讨宫颈病变合并高危型人乳头状瘤病毒(HR-HPV)持续性感染患者外周血Th1/Th2平衡状况及临床意义。方法回顾性选取2022年3月至2024年5月南阳市中医院收治的103例HR-HPV持续感染患者作为研究组,依据宫颈活检病理结果将其分为无宫颈病变组17例、低级别上皮内瘤变组34例、高级别上皮内瘤变组29例及宫颈癌组23例;选择同期于南阳市中医院治疗并随访的86例HR-HPV转阴患者作为对照组。比较研究组患者与对照组的外周血Th1(白介素-2、干扰素-γ)、Th2细胞因子(白介素-4、白介素-6、白介素-10水平)水平;比较研究组中HP-HPV持续感染有无宫颈病变患者的外周血Th1、Th2细胞因子水平;比较研究组中不同宫颈病变的HP-HPV持续感染患者的外周血Th1、Th2细胞因子水平。结果研究组患者的白介素-2、干扰素-γ水平分别为(2.33±0.35)pg/mL、(7.59±1.01)pg/mL,明显低于对照组的(4.90±0.15)pg/mL、(12.80±1.53)pg/mL,白介素-4、白介素-6、白介素-10水平分别为(15.89±1.63)pg/mL、(24.29±2.17)pg/mL、(27.69±2.90)pg/mL,明显高于对照组的(7.72±0.84)pg/mL、(6.90±0.73)pg/mL、(8.14±1.15)pg/mL,差异均有统计学意义(P<0.05)。HP-HPV持续感染合并宫颈病变组患者的白介素-2、干扰素-γ水平分别为(2.17±0.38)pg/mL、(7.09±1.05)pg/mL,明显低于HP-HPV持续感染无宫颈病变组的(3.13±0.42)pg/mL、(10.12±0.81)pg/mL,白介素-4、白介素-6、白介素-10水平分别为(17.29±1.75)pg/mL、(26.61±2.40)pg/mL、(30.05±3.01)pg/mL,明显高于HP-HPV持续感染无宫颈病变组的(8.81±1.02)pg/mL、(12.55±1.01)pg/mL、(15.75±2.34)pg/mL,差异均有统计学意义(P<0.05)。宫颈癌组患者白介素-2、干扰素-γ水平分别为(1.55±0.26)pg/mL、(4.95±0.62)pg/mL,明显低于高级别上皮内瘤变组的(1.75±0.37)pg/mL、(6.18±0.74)pg/mL及低级别上皮内瘤变组的(2.95±0.49)pg/mL、(9.31±1.63)pg/mL,白介素-4、白介素-6、白介素-10水平分别为(25.87Objective To investigate the peripheral blood Th1/Th2 balance and its clinical significance in patients with cervical lesions and persistent high-risk human papillomavirus(HR-HPV)infection.Methods A retrospective study included 103 patients with persistent HR-HPV infection admitted to Nanyang Traditional Chinese Medicine Hospital from March 2022 to May 2024(study group).Based on cervical biopsy pathology,they were divided into four subgroups:17 cases without cervical lesions,34 cases with low-grade intraepithelial neoplasia,29 cases with high-grade intraepithelial neoplasia,and 23 cases with cervical cancer.Additionally,86 patients with HR-HPV clearance during follow-up were selected as the control group.Peripheral blood levels of Th1 cytokines(interleukin-2[IL-2],interferon-γ[IFN-γ])and Th2 cytokines(IL-4,IL-6,IL-10)were compared between the study and control groups,between HR-HPV-positive patients with or without cervical lesions,and among different cervical lesion subgroups in the study group.Results The study group showed significantly lower Th1 cytokine levels and higher Th2 cytokine levels compared to the control group(P<0.05):IL-2,(2.33±0.35)pg/mL vs(4.90±0.15)pg/mL;IFN-γ,(7.59±1.01)pg/mL vs(12.80±1.53)pg/mL;IL-4,(15.89±1.63)pg/mL vs(7.72±0.84)pg/mL;IL-6,(24.29±2.17)pg/mL vs(6.90±0.73)pg/mL;IL-10,(27.69±2.90)pg/mL vs(8.14±1.15)pg/mL.The levels of IL-2 and IFN-γin HR-HPV-positive patients with cervical lesions were(2.17±0.38)pg/mL and(7.09±1.05)pg/mL,which was significantly lower than(3.13±0.42)pg/mL and(10.12±0.81)pg/mL in HR-HPV-positive patients without cervical lesions;the levels of IL-4,IL-6,and IL-10 were(17.29±1.75)pg/mL,(26.61±2.40)pg/mL,and(30.05±3.01)pg/mL,which was significantly higher than(8.81±1.02)pg/mL,(12.55±1.01)pg/mL,and(15.75±2.34)pg/mL in HR-HPV-positive patients without cervical lesions;the differences were statistically significant(P<0.05).The levels of IL-2 and INF-γin cervical cancer subgroup were(1.55±0.26)pg/mL and(4.95±0.62)pg/mL,which was significantly

关 键 词：宫颈病变 高危型人乳头状瘤病毒 T1/Th2 细胞因子 临床意义 

分 类 号：R711.74[医药卫生—妇产科学]