TBNK淋巴细胞亚群检测与儿童重症肺炎的相关性分析  

Analysis of the correlation between TBNK lymphocyte subsets testing and severe pneumonia in children

作　　者：周丽岩 冯荣光 ZHOU Liyan;FENG Rongguang(Department of Paediatrics,Chifeng City Hospital,Chifeng,Inner Mongolia 024000,China;Department of Pediatric Medicine,Inner Mongolia Autonomous Region Maternal and Child Health Hospital,Hohhot,Inner Mongolia 010020,China)

机构地区：[1]赤峰市医院儿科,内蒙古赤峰024000 [2]内蒙古自治区妇幼保健院儿内科,内蒙古呼和浩特010020

出　　处：《临床肺科杂志》2025年第4期566-569,共4页Journal of Clinical Pulmonary Medicine

基　　金：内蒙古自治区卫生科技计划项目(202201132)。

摘　　要：目的探讨TBNK淋巴细胞亚群检测与儿童重症肺炎的相关性。方法选取2021年1月至2023年12月内蒙古自治区妇幼保健院儿内科收治的肺炎住院患儿120例为研究对象,其中重症肺炎组60例,普通肺炎组60例。收集两组患儿一般资料以及临床资料,包括淋巴细胞亚群、血常规、CRP、PCT、IL-6检测结果。比较两组患儿淋巴细胞亚群及血常规等指标的差异性,统计分析淋巴细胞亚群各项指标与肺炎患儿重症肺炎发生的相关性。结果(1)重症肺炎组CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)、CD19^(+)、CD16^(+)CD56^(+)计数以及CD3^(+)%、CD3^(+)CD4^(+)%均低于普通肺炎组(P<0.05),CD19^(+)%高于普通肺炎组(P<0.05),CD3^(+)CD8^(+)%、CD16^(+)CD56^(+)%在两组中未见显著差异性。(2)淋巴细胞亚群检测中CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)与重症肺炎结局的发生呈显著负相关(P<0.001)。结论T淋巴细胞计数与儿童重症肺炎的发生具有显著相关性。Objective To explore the correlation between TBNK lymphocyte subsets testing and severe pneumonia in children.Methods 120 cases of hospitalized children with pneumonia admitted to the pediatric department of Inner Mongolia Autonomous Region Maternal and Child Health Hospital from January 2021 to December 2023 were selected for the study,including 60 cases in the severe pneumonia group and 60 cases in the common pneumonia group.Their general data and clinical data were collected,including the results of lymphocyte subsets,blood routine,CRP,PCT and IL-6 tests.The differences in lymphocyte subsets and other indicators such as blood routine were compared between the two groups,and the correlation between lymphocyte subsets and the occurrence of severe pneumonia in children was statistically analyzed,and the predictive value of T-lymphocyte levels for severe pneumonia was calculated.Results(1)CD3^(+),CD3^(+)CD4^(+),CD3^(+)CD8^(+),CD19^(+),CD16^(+)CD56^(+)counts as well as CD3^(+)%and CD3^(+)CD4^(+)%were lower in the severe pneumonia group than those in the common pneumonia group(P<0.05),and CD19^(+)%was higher than that in the common pneumonia group(P<0.05),and CD3^(+)CD8^(+)%,CD16^(+)CD56^(+)%did not show a significant difference between the two groups.(2)CD3^(+),CD3^(+)CD4^(+),and CD3^(+)CD8^(+)in the lymphocyte subsets assay were significantly and negatively associated with the development of severe pneumonia outcomes.Conclusion T-lymphocyte counts are significantly associated with the development of severe pneumonia in children.

关 键 词：淋巴细胞亚群 儿童 重症肺炎 

分 类 号：R725.6[医药卫生—儿科]