阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者颈动脉内膜中层厚度的影响因素  

Analysis of influencing factors on carotid intima-media thickness in patients with obstructive sleep apnea-hypopnea syndrome and type 2 diabetes

作　　者：薛小飞 付荣 韩宁波[1] XUE Xiaofei;FU Rong;HAN Ningbo(Department of Endocrinology,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China;Department of Electrophysiology,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China)

机构地区：[1]定州市人民医院内分泌科,河北定州073000 [2]定州市人民医院电生理科,河北定州073000

出　　处：《临床肺科杂志》2025年第4期592-596,共5页Journal of Clinical Pulmonary Medicine

基　　金：河北省医学科学研究课题计划(20220435)。

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者颈动脉内膜中层厚度的影响因素。方法采取便利抽样的原则,选择2019年1月-2022年12月接受治疗的OSAHS合并2型糖尿病患者100人的数据资料实施回顾性分析。依据患者的OSAHS病情严重程度,实施分组,A组(轻度)32人,B组(中度)48人,C组(重度)20人。对比各组患者的一般临床资料。对比各组患者的颈动脉内膜中层厚度(IMT)、血清超敏C-反应蛋白、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSaO_(2))。分析颈动脉IMT和各指标的相关性。分析OSAHS合并2型糖尿病患者颈动脉IMT的独立影响因素。结果不同分组患者的体质量指数的数据差异具有统计学意义(P<0.05)。不同分组患者的颈动脉IMT、血清超敏C-反应蛋白、AHI、夜间LSaO_(2)的数据差异具有统计学意义(P<0.05)。颈动脉IMT和体质量指数、血清超敏C-反应蛋白、AHI呈正相关,颈动脉IMT和夜间LSaO_(2)呈负相关(P<0.05)。体质量指数、血清超敏C-反应蛋白、AHI、夜间LSaO_(2)均是OSAHS合并2型糖尿病患者颈动脉IMT的独立影响因素(调整R^(2)=0.875,F=173.971,P<0.05)。结论体质量指数、血清超敏C-反应蛋白、AHI、夜间LSaO_(2)均是OSAHS合并2型糖尿病患者颈动脉IMT的独立影响因素。Objective To explore the influencing factors of carotid intima-media thickness in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes.Methods Based on the principle of convenience,the data of 100 patients with OSAHS combined with type 2 diabetes from January 2019 to December 2022 were selected for retrospective analysis.According to the severity of OSAHS,the patients were divided into 32 patients in group A(mild),48 in group B(moderate),and 20 in group C(severe).The general clinical data of each group were compared.Carotid intima-media thickness(IMT),serum hypersensitive C-reactive protein,apnea-hypopnea index(AHI),and lowest oxygen saturation at night(LSaO_(2))were compared among all groups.The correlation between carotid IMT and each index was analyzed.To analyze the independent influencing factors of carotid IMT in patients with OSAHS and type 2 diabetes.Results The data on body mass index of patients in different groups had statistical significance(P<0.05).There were significant differences in carotid IMT,serum hypersensitive C-reactive protein,AHI,and nocturnal LSaO_(2)among patients in different groups(P<0.05).Carotid artery IMT showed a positive correlation with body mass index,serum high-sensitivity C-reactive protein,and AHI,while carotid artery IMT showed a negative correlation with nighttime LSaO_(2)(P<0.05).Body mass index,serum hypersensitive C-reactive protein,AHI,and nocturnal LSaO_(2)were all independent influencing factors of carotid IMT in OSAHS patients with type 2 diabetes(adjusted R^(2)=0.875,F=173.971,P<0.05).Conclusion Body mass index,serum high-sensitivity C-reactive protein,AHI,and nocturnal LSaO_(2)are independent influencing factors of carotid IMT in OSAHS patients with type 2 diabetes.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 2型糖尿病 动脉粥样硬化 超敏C-反应蛋白 体质量指数 

分 类 号：R766[医药卫生—耳鼻咽喉科] R587.1[医药卫生—临床医学]