基于数据挖掘技术分析肖纯治疗头痛用药规律  

Analysis of Medication Rules of XIAO Chun in Treating Headaches Based on Data Mining Technology

作　　者：施超琼 庄逸洋 卢茵茵 常晴晴 毕尚青 肖纯(指导) SHI Chaoqiong;ZHUANG Yiyang;LU Yinyin;CHANG Qingqing;BI Shangqing;XIAO Chun(The Seventh Clinical College of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518100,China;Shenzhen Bao'an Traditional Chinese Medicine Hospital Group,Shenzhen Guangdong 518100,China)

机构地区：[1]广州中医药大学第七临床医学院,广东深圳518100 [2]深圳市宝安中医院(集团),广东深圳518100

出　　处：《新中医》2025年第6期1-6,共6页New Chinese Medicine

基　　金：广东省名中医传承工作室建设资助项目(粤中医办函〔2020〕1号);2024年深圳市宝安区区属公立医院高质量发展项目(YNXM2024018);深圳市宝安区医疗卫生科研项目(2022JD208)。

摘　　要：目的:基于数据挖掘技术分析肖纯教授治疗头痛的用药规律。方法:收集2023年1月1日—2024年5月31日深圳市宝安中医院(集团)肖纯教授门诊辨治有效的头痛病历。使用中医传承辅助平台(V2.5)统计药物使用频次及性味归经,运用关联规则分析总结常用药物组合、聚类分析提取新方。结果:共纳入251首处方,涉及中药123味,使用总频次为4535次。使用频次排前10位的中药依次为大枣、细辛、川芎、白芷、附子、甘草、牛膝、防风、天麻、石南藤。药性以温、平为主,药味以辛、甘为主,归经以归肝、脾、肺、心经居多。大枣、细辛,白芷、川芎为出现频次排名前2位的常用药物组合,细辛、附子、大枣为置信度最高的常用药物组合的关联规则。根据关联规则和聚类分析得到高频药物组合8对,经筛选得到合理的新方组合3首(甘草、桂枝、牡蛎、丹参、黄柏;干姜、桂枝、当归、乌梅、天麻、防风、牛膝;半夏、木香、紫苏叶、附子、通草)。结论:肖纯教授善用补虚药、解表药、活血化瘀药、温里药、平肝熄风药、祛风湿药、安神药治疗头痛,喜用白芷、川芎药对祛风止痛,细辛、附子、大枣药物组合温阳散寒止痛,注重标本兼治、补虚泻实,用药平和。Objective:To explore the medication rules of Professor XIAO Chun in treating headaches based on data mining technology.Methods:Effective outpatient headache case histories treated by Professor XIAO Chun from Shenzhen Bao'an Traditional Chinese Medicine Hospital Group between January 1,2023,and May 31,2024 were collected.The Traditional Chinese Medicine Inheritance Support System(V2.5)was used to count the frequency of herbal use and their natures,flavors,and channel entries.Association rule analysis was employed to summarize commonly used herbal combinations,and cluster analysis was conducted to extract new prescriptions.Results:A total of 251 prescriptions involving 123 Chinese herbs with a total use frequency of 4535 times were included.The top 10 herbs in terms of use frequency were Jujubae Fructus,Asari Radix et Rhizoma,Chuanxiong Rhizoma,Angelicae Dahuricae Radix,Aconiti Lateralis Radix Praeparata,Glycyrrhizae Radix et Rhizoma,Achyranthis Bidentatae Radix,Saposhnikoviae Radix,Gastrodiae Rhizoma and Piper wallichii Caulis et Folium.The medicinal natures were mainly warm and neutral,the flavors were mainly acrid and sweet,and the channel entries were mainly the liver,spleen,lung,and heart channels.Jujubae Fructus-Asari Radix et Rhizoma and Angelicae Dahuricae Radix-Chuanxiong Rhizoma were the top two most frequently used herbal combinations.The association rule with the highest confidence was that of Asari Radix et Rhizoma,Aconiti Lateralis Radix Praeparata and Jujubae Fructus.Based on association rules and cluster analysis,eight pairs of high-frequency herbal combinations were obtained,and three new prescription combinations were screened(Glycyrrhizae Radix et Rhizoma,Cinnamomi Ramulus,Ostreae Concha,Salviae Miltiorrhizae Radix et Rhizoma and Phellodendri Chinensis Cortex;Zingiberis Rhizoma,Cinnamomi Ramulus,Angelicae Sinensis Radix,Mume Fructus,Gastrodiae Rhizoma,Saposhnikoviae Radix and Achyranthis Bidentatae Radix;Pinelliae Rhizoma,Aucklandiae Radix,Perillae Folium,Aconiti Lateralis Radix Praeparata and Te

关 键 词：头痛 中医传承辅助平台 数据挖掘 用药规律 肖纯 

分 类 号：R277.7[医药卫生—中医学]