基于数据挖掘分析高雪治疗肺结节用药规律  

Analysis of Medication Rules of GAO Xue for Treating Pulmonary Nodules Based on Data Mining

作　　者：叶廷林 高雪[2] 罗瑞琪 刘玉[2] YE Tinglin;GAO Xue;LUO Ruiqi;LIU Yu(The Fourth School of Clinical Medicine,Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518033,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen Guangdong 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《新中医》2025年第6期25-31,共7页New Chinese Medicine

基　　金：国家自然科学基金项目(81904103);深圳市科技计划项目(JCYJ20190812155412785,JCYJ20210324111204013,JCYJ20230807094606014)。

摘　　要：目的:基于中医传承计算平台,运用数据挖掘方法分析高雪教授治疗肺结节的用药规律。方法:收集整理2021年9月—2022年12月就诊于高雪教授门诊的肺结节患者病例资料,构建门诊数据库。使用中医传承平台(V3.0)对处方药物的频次、四气、五味、归经、功效及关联规则、核心组合进行挖掘,分析高雪教授防治肺结节的用药经验。结果:共纳入处方121首,涉及药物119味,总使用频次数达2047次。常用药物30味,药物以化痰药、清热药、解表药、补虚药及理气药为主;四气统计温性药物最多,寒性药次之;药味使用数最多的是辛味和苦味药;归经统计归肺经、脾经、胃经的药物最常用;常用药物组合31个,根据K-means算法聚类分析结合临床经验得到常用特色药对3组。结论:高雪教授临床治疗肺结节,基于“肺系伏邪”的理论基础,总以祛邪为主,以化痰散结贯穿始终,辅以清热祛湿、活血化瘀、宣肺行气等治法。Objective:To analyze the medication rules of Professor GAO Xue in treating pulmonary nodules with the application of data mining based on the Traditional Chinese Medicine Inheritance Computing System.Methods:Case data of lung nodule patients who visited Professor GAO Xue's clinic from September 2021 to December 2022 were collected and organized to construct an outpatient database.Traditional Chinese Medicine Inheritance Computing System(V3.0)was used to explore the frequency,four qi,five flavors,meridian entries,efficacy,association rules,and core combinations of prescription medicinals,and summarize Professor GAO Xue's medication experience in preventing and treating pulmonary nodules.Results:A total of 121 prescriptions were included,involving 119 Chinese medicinals,with a total usage frequency of 2047 times.There were 30 commonly used Chinese medicinals,mainly including phlegm-resolving medicinals,heat-clearing medicinals,exterior-releasing medicinals,deficiency-tonifying medicinals,and qi-regulating medicinals;the statistics for the four qi showed that warm medicinals were the most common,followed by cold medicinals;the most commonly used medicinal flavors were acrid and bitter;the most commonly meridian entries were the lung,the spleen,and the stomach meridians.There were 31 commonly used medicinal combinations,and three commonly used characteristic couplets were obtained through clustering analysis using K-means algorithm combined with clinical experience.Conclusions:Professor GAO Xue's clinical treatment of pulmonary nodules is based on the theory of"latent pathogen in the lung",with the main focus on dispelling pathogens,resolving phlegm and dissipating masses throughout,and supplemented by methods such as clearing heat and dispelling dampness,promoting blood circulation and removing blood stasis,and diffusing the lung and moving qi.

关 键 词：肺结节 数据挖掘 用药规律 化痰散结 名医经验 高雪 

分 类 号：R563[医药卫生—呼吸系统]