成人氨氯地平中毒剂量与休克程度相关性研究  

A correlation study between drug dose and shock severity in adults with amlodipine poisoning

作　　者：李辉[1,2] 张华[3] 付源伟[1,2] 郭治国 马青变[1,2] Li Hul;Zhang Huad;Fu Yuanwei;Guo Zhiguo;Ma Qingbian(Emergency Department,Peking University Third Hospital,Bejing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China;Research Center of Clinical Epidemiology,Peking University Third Hospital,Bejing 100191,China)

机构地区：[1]北京大学第三医院急诊科,北京100191 [2]分子心血管学教育部重点实验室,北京1100191 [3]北京大学第三医院临床流行病学研究中心,北京100191

出　　处：《中华急诊医学杂志》2025年第3期359-368,共10页Chinese Journal of Emergency Medicine

基　　金：国家临床重点专科建设项目(2022)专项资金(301-2305)。

摘　　要：目的 通过分析氨氯地平中毒合并休克患者临床资料,分析剂量与休克严重程度的关系。方法 选取2018年1月1日至2022年12月31日因氨氯地平中毒并发休克在北京大学第三医院急诊科救治的成年患者并检索1997一2022年公开发表的氨氯地平中毒文献中合并休克的成年患者,分为非难治性休克组和难治性休克组,对两组间的数据进行统计学分析。结果 共纳人80例患者,其中非难治性休克的患者37例,难治性休克43例,两组间性别(P=0.037)、服药剂量差异有统计学意义(P=0.001)。将性别、年龄、剂量、是否混合中毒进行二元Logistic回归分析,结果显示剂量是休克严重程度的独立影响因素(OR=1.43,95%CI:1.12~1.84,P=0.005)。亚组分析将仅服用氨氯地平未同服其他药物而中毒的非难治性休克和难治性休克的两组患者进行比较,两组间服药剂量同样差异有统计学意义(P=0.003)。用受试者工作曲线对中毒剂量和难治性休克进行分析,曲线下面积AUC为0.723(95%CI:0.613~0.833),最佳界值剂量为347.5mg(敏感度0.651、特异度0.784)。敏感性分析(不包括混合中毒病例)得出的AUC较高,为0.795(95%CI:0.634~0.956),最佳界值剂量为350mg(敏感度0.867,特异度0.737)。服药剂量和难治性休克发生率的剂量反应关系表显示,随着剂量的增大,发生难治性休克的比例也随之增加。结论 在因超量服用氨氯地平引起中毒的成人患者中,药物剂量与休克的严重程度相关,当剂量大于347.5mg时要高度警惕难治性休克的发生,给予更多临床关注,调配更多医疗资源。Objective This study aimed to investigate the correlation between the ingested dose of amlodipine and the severity of shock in affected patients by analyzing clinical data from documented cases.Methods This study respectively included adult patients treated for amlodipine poisoning-induced shock at the emergency department of Peking University Third Hospital between January 2018 and December 2022.Additionally,cases reported in the literature from January 1997 to December 2022 were also included.Patients were categorized into two groups:non-refractory shock and refractory shock.Statistical analysis was conducted on the data between the two groups.Results This study included a total of 80 patients,with 37 experiencing non-refractory shock patients and 43 presenting with refractory shock patients.Significant differences were observed between the two groups in terms of sex distribution(P=0.037)and the ingested amlodipine dose(P=0.001).Through binary logistic regression analysis,the amlodipine dose was identified as an independent predictor of shock severity(OR=1.43,95%CI:1.12-1.84,P=0.005).A subgroup analysis was performed on patients who were poisoned by ingesting amlodipine alone,further confirming the significant dose difference(P=0.003)between the non-refractory shock and refractory shock categories.The area under the receiver operating characteristic curve(AUC)for predicting refractory shock in patients with amlodipine poisoning was 0.723(95%CI:0.613-0.833).The optimal cutoff dose for predicting refractory shock was 347.5 mg,with a sensitivity of 0.651 and a specificity of 0.784.Sensitivity analyses,excluding cases of mixed poisoning,yielded a higher AUC of 0.795(95%CI:0.634-0.956),with a slightly adjusted cutoff dose of 350 mg,a sensitivity of 0.867,and a specificity of 0.737.The dose-response relationship table between medication dosage and incidence of refractory shock shows that as the dosage increases,the proportion of refractory shock also increases.Conclusions In adult patients with amlodipine poisoning,t

关 键 词：心血管药物 钙通道阻滞剂 氨氯地平 中毒 剂量 休克 难治性休克 剂量反应关系 

分 类 号：R47[医药卫生—护理学]