黄芩柴胡茯苓汤联合熊去氧胆酸片对妊娠期肝内胆汁淤积症患者血清氧化应激水平及母婴结局的影响  

Effects of Huangqin Chaihu Fuling Decoction Combined with Ursodeoxycholic Acid Tablets on Serum Oxidative Stress Levels and Maternal and Infant Outcome in Patients with Intrahepatic Cholestasis of Pregnancy

作　　者：王红 WANG Hong(Department of Gynecology and Obstetrics,the First People's Hospital of Zunyi,Zunyi 563000,China)

机构地区：[1]遵义市第一人民医院(遵义医科大学第三附属医院)妇产科,贵州遵义563000

出　　处：《中国医学创新》2025年第9期60-64,共5页Medical Innovation of China

摘　　要：目的:探讨在妊娠期肝内胆汁淤积症患者中联合应用黄芩柴胡茯苓汤与熊去氧胆酸片的治疗效果。方法:纳入遵义市第一人民医院2019年1月—2024年1月收治的106例妊娠期肝内胆汁淤积症患者,以随机数字表法分为对照组(n=53,予以熊去氧胆酸片治疗)与研究组(n=53,予以熊去氧胆酸片+黄芩柴胡茯苓汤治疗)。比较两组疗效、血清氧化应激指标[超氧化物歧化酶(SOD)、脂质过氧化物(LPO)、丙二醛(MDA)]、肝功能指标[天冬氨酸转氨酶(AST)、总胆红素(TBIL)、丙氨酸转氨酶(ALT)、总胆汁酸(TBA)]、不良妊娠结局及新生儿Apgar评分。结果:研究组总有效率为96.23%,明显高于对照组的81.13%(P<0.05);治疗1周后,研究组SOD高于对照组,LPO、MDA均低于对照组(P<0.05);治疗1周后,研究组AST、TBIL、ALT及TBA水平均低于对照组(P<0.05);研究组不良妊娠结局发生率为5.66%,较对照组的22.64%低,新生儿出生5 min Apgar评分高于对照组(P<0.05)。结论:在妊娠期肝内胆汁淤积症患者中联合应用黄芩柴胡茯苓汤与熊去氧胆酸片可获得较良好的疗效,可减轻氧化应激反应,改善肝功能及母婴结局。Objective:To investigate the therapeutic effect of Huangqin Chaihu Fuling Decoction combined with Ursodeoxycholic Acid Tablets on serum oxidative stress levels and maternal and infant outcome in patients with intrahepatic cholestasis of pregnancy.Method:A total of 106 patients with intrahepatic cholestasis of pregnancy admitted to the First People's Hospital of Zunyi from January 2019 to January 2024 were included and divided into the control group(n=53,treated with Ursodeoxycholic Acid Tablets)and the study group(n=53,treated with Ursodeoxycholic Acid Tablets+Huangqin Chaihu Fuling Decoction)by random number table method.The therapeutic effect,serum oxidative stress indexes[superoxide dismutase(SOD),lipid peroxide(LPO),malondialdehyde(MDA)],liver function indexes[aspartate aminotransferase(AST),total bilirubin(TBIL),alanine aminotransferase(ALT),total bile acid(TBA)],adverse pregnancy outcome and neonatal Apgar score were compared between the two groups.Result:The total effective rate of the study group was 96.23%,which was significantly higher than 81.13%of the control group(P<0.05).After 1 week of treatment,SOD in the study group was higher than that in the control group,LPO and MDA were lower than those in the control group(P<0.05).After 1 week of treatment,the levels of AST,TBIL,ALT and TBA in the study group were lower than those in the control group(P<0.05).The incidence of adverse pregnancy outcome in the study group was 5.66%,which was lower than 22.64%in the control group,and the neonatal Apgar score 5 min after birth was higher than that in the control group(P<0.05).Conclusion:In the patients with intrahepatic cholestasis of pregnancy,the combination of Huangqin Chaihu Fuling Decoction combined with Ursodeoxycholic Acid Tablets can obtain good curative effect,reduce oxidative stress reaction,improve liver function and maternal and infant outcome.

关 键 词：妊娠期肝内胆汁淤积症 熊去氧胆酸片 黄芩柴胡茯苓汤 氧化应激 母婴结局 

分 类 号：R28[医药卫生—中药学]