药物涂层球囊在下肢动脉硬化闭塞症治疗中的应用现状及问题  

Applications and problems of drug-coated balloons in the treatment of arteriosclerosis obliterans of the lower extremities

作　　者：谢海 张友嘉 李晓强 冉峰[1] Xie Hai;Zhang Youjia;Li xiaoqiang;Ran Feng(Department of Vascular Surgery,Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing210000,China)

机构地区：[1]南京大学医学院附属鼓楼医院血管外科,南京210000

出　　处：《中华血管外科杂志》2024年第6期402-406,共5页Chinese Journal of Vascular Surgery

基　　金：江苏省基础研究计划自然科学基金(BK20231121)。

摘　　要：下肢动脉硬化闭塞症(ASO)是临床上最常见的下肢动脉疾病,由于动脉管腔狭窄和闭塞,可能引起严重的肢体缺血。血管腔内介入治疗已成为ASO的主流治疗方式,药物涂层球囊(DCB)通过靶向输送抗内膜增殖药物来抑制内膜增生,降低手术后的再狭窄率,并因在血管腔内不留下任何置入物的优点得到了广泛应用,逐渐成为ASO血管腔内介入治疗的重要手段,因此本文对DCB在下肢ASO中的应用现状和面临的问题进行综述。Arteriosclerosis obliterans(ASO)is one of the most common lower extremity artery disease in clinical practice as arterial lumen stenosis and occlusion may cause critical limb ischemia.Endovascular interventional therapy has become the mainstream treatment for ASO.Drug-coated balloon(DCB)inhibits intimal hyperplasia and reduces the restenosis rate after surgery by delivering antiproliferative drugs to the target area.In addition,DCB has been widely used for its advantage of leaving no implant in the vascular lumen,and has gradually become an important means of intravascular interventional therapy in ASO.Therefore,this paper aims to review the application status and problems of DCB in treating ASO.

关 键 词：药物涂层球囊 下肢动脉硬化闭塞症 腔内治疗 支架内再狭窄 

分 类 号：R54[医药卫生—心血管疾病]