促进小口径人工血管内皮化的研究进展  

Research progress in promoting endothelialization of small-diameter artificial blood vessel

作　　者：毕现茹 郝迎学 Bi Xianru;Hao Yingxue(Department of Vascular Surgery,The First Hospital Affiliated to the Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学第一附属医院血管外科,重庆400038

出　　处：《中华血管外科杂志》2024年第6期407-410,共4页Chinese Journal of Vascular Surgery

基　　金：国家自然科学基金(82370484);重庆市自然科学基金(CSTB2023NSCQ-MSX0525)。

摘　　要：小口径人工血管因植入早期易形成血栓而导致通畅率降低,至今仍处于临床研究阶段,保持其长期通畅的方法是实现内皮化。本文通过查阅近年来国内外文献,总结了促进小口径人工血管内皮化的三种策略即负载抗血栓化合物、原位募集内皮祖细胞及选用天然生物材料,为今后小口径人工血管的研究提供参考。Small-diameter artificial blood vessel is still at the stage of clinical research because of its reduced patency rate as it is easy to form thrombosis in the early stage of implantation.Endothelialization is a way to maintain long-term patency.This article summarizes three strategies to promote the endothelialization of small-diameter artificial blood vessel by reviewing the literature in recent years,namely loading antithrombotic drugs,recruiting endothelial progenitor cells in situ,and selecting natural biological materials,aiming to provide references for future research in small-caliber artificial vessels.

关 键 词：小口径人工血管 内皮化 血栓形成 

分 类 号：R318.08[医药卫生—生物医学工程]