PFAS高分辨率质谱数据的非靶标识别技术综述  

A review on the nontarget identification technology for PFAS by using high resolution mass spectrometry

作　　者：孟祥周[1,2,3] 张博暄 韩宝苍 朱清禾 杨洁 张敏超 Meng Xiangzhou;Zhang Boxuan;Han Baocang;Zhu Qinghe;Yang Jie;Zhang Minchao(College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China;Ministry of Ecology and Environment Engineering Center for Urban Soil Contamination Control and Remediation,Shanghai Academy of Environmental Sciences,Shanghai 200233,China;Jiaxing Tongji Environmental Research Institute,Jiaxing 314051,China;Technical Center for Industrial Products and Raw Materials Inspection and Testing of Shanghai Customs District,Shanghai 201210,China)

机构地区：[1]同济大学环境科学与工程学院,上海200092 [2]上海市环境科学研究院生态环境部城市土壤污染控制与修复工程技术中心,上海200233 [3]嘉兴同济环境研究院,浙江嘉兴314051 [4]上海海关工业品与原材料检测技术中心,上海201210

出　　处：《河南师范大学学报(自然科学版)》2025年第3期1-11,F0002,共12页Journal of Henan Normal University(Natural Science Edition)

基　　金：国家自然科学基金(42177378);国家环境保护城市土壤污染控制与修复工程技术中心开放基金(USCR-202202);嘉兴市公益性研究计划项目(2023AY11053);上海市法医学重点实验室暨司法部司法鉴定重点实验室开放课题(KF202422).

摘　　要：全氟及多氟烷基物质(per-and polyfluoroalkyl substances,PFAS)使用广泛,在环境中难以降解,且具有生物富集性、迁移性和毒性,引发全球关注.PFAS种类繁多,基于高分辨率质谱的非靶标分析是发现环境中未知PFAS的主要方法,而高效识别技术是其中的难点.系统梳理了PFAS非靶标识别技术的框架,总结了不同PFAS非靶标识别策略的应用情况与优缺点,比较了不同PFAS非靶标识别开源软件的特点,以期为环境未知PFAS的精准识别、溯源和管控提供科技支撑.Per-and polyfluoroalkyl substances(PFAS)have been widely used in various commercial products,which raised global concerns because of their persistence,bioaccumulation,mobility,and toxicity.Large unknown PFAS in the environment are generally identified by using nontarget analysis with high-resolution mass spectrometry,however,the development of fast and efficient identification technology is difficult and urgent.This review aims to draw the framework of nontarget identification technology for PFAS,to summarize the application,advantages and disadvantages of different nontarget identification strategies,and to compare the open-source nontarget identification software.The results are helpful for the precise identification,source exploration and control of novel PFAS in the environment.

关 键 词：全氟及多氟烷基物质(PFAS) 高分辨率质谱(HRMS) 非靶标识别 疑似筛查 新污染物 

分 类 号：X502[环境科学与工程—环境工程]