激酶/转录因子信号通路调控肺癌机制及中医药干预的研究进展  

Research Progress on the Regulation Mechanism of Lung Cancer by Kinase/Transcription Factor Signaling Pathway and Traditional Chinese Medicine Intervention

作　　者：吴杨 隋雨桐 李斌鹏 韩路拓 姜家康[1,2] WU Yang;SUI Yutong;LI Binpeng;HAN Lutuo;JIANG Jiakang(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Shenzhen Hospital of Southern Medical University,Shenzhen 518110,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040 [3]南方医科大学深圳医院,深圳518110

出　　处：《世界中医药》2025年第1期142-147,154,共7页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82104585);黑龙江省博士后资助项目(LBH-Z22288)。

摘　　要：非小细胞肺癌(NSCLC)是原发性肺癌的主要病理类型,约占肺癌的85%,肺癌的发病率占所有恶性肿瘤的第二位,大多数患者确诊时已属于晚期,失去了最佳手术机会,化放疗治疗带来的损伤使患者依从性差,往往不能获得满意的效果。中医药具有多通路,多靶点的作用,且能减轻放化疗的损伤,提高患者的生命质量,延长生存期,为晚期肺癌患者带来了曙光。研究发现,肺癌受许多信号通路调控,蛋白酪氨酸激酶(JAK)/信号转导及转录激活因子(STAT)信号通路是关键调控信号通路之一,JAK/STAT信号通路通过调节细胞周期、抑制肺癌细胞的凋亡以及促进肺癌细胞的血管生成,影响肺癌细胞的增殖、侵袭和转移。通过检索文献发现,中药复方及单体通过JAK/STAT信号通路在NSCLC的增殖、转移以及凋亡的过程中发挥着不可或缺的作用,并且越来越多的动物实验开始不断研究中药通过JAK/STAT信号通路影响肺癌的作用机制。Non-small cell lung cancer(NSCLC)is the main pathological type of primary lung cancer,accounting for approximately 85%of lung cancer cases.Lung cancer ranks second in terms of incidence among all malignant tumors.Most patients are diagnosed at an advanced stage,missing the optimal opportunity for surgery.The damage caused by chemotherapy and radiation therapy leads to poor patient adherence,often resulting in unsatisfactory outcomes.Traditional Chinese medicine(TCM)has multi-pathway,multi-target effects,and can reduce the damage caused by chemotherapy and radiation,improving the patient′s quality of life and extending survival,offering hope for patients with advanced lung cancer.Research has shown that lung cancer is regulated by numerous signaling pathways,with the Janus kinase(JAK)/signal transducer and activator of transcription protein(STAT)pathway being one of the key regulatory pathways.The JAK/STAT pathway affects lung cancer cell proliferation,invasion,and metastasis by regulating the cell cycle,inhibiting apoptosis,and promoting angiogenesis.Literature reviews have found that both TCM formulas and single compounds play an indispensable role in the proliferation,metastasis,and apoptosis of NSCLC cells through the JAK/STAT signaling pathway.Increasing animal studies are exploring the mechanisms by which TCM influences lung cancer through the JAK/STAT pathway.

关 键 词：蛋白酪氨酸激酶/信号转导及转录激活因子 信号通路 作用机制 肺癌 中药单体 中药复方 研究进展 

分 类 号：R273[医药卫生—中西医结合]