肉毒素A治疗难治性膀胱过度活动症的研究进展  

Research progress on botulinum toxin-ain the treatment of refractory overactive bladder

作　　者：牟健 杜建辉 蓝建华[1] 金涛[2,3] MOU Jian;DU Jian-hui;LAN Jian-hua;JIN Tao(Department of Urology,Guang'an People's Hospital,Guang'an 638000,China;Department of Urology,Institute of Urology,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Urology,West China Tianfu Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川省广安市人民医院泌尿外科,四川广安638000 [2]四川大学华西医院泌尿外科/四川大学华西医院泌尿外科研究所,四川成都610041 [3]四川大学华西天府医院泌尿外科,四川成都610041

出　　处：《实用医院临床杂志》2025年第2期2-8,共7页Practical Journal of Clinical Medicine

基　　金：国家科技部国家重点研发计划(编号:2023YFC3606000);国家卫健委科研基金资助项目(编号:WKZX2023JG0228)。

摘　　要：对于难治性的膀胱过度活动症(OAB)患者,膀胱内注射A型肉毒毒素(BTX-A)是一项安全、有效的治疗手段,其通过干扰神经传导钙离子依赖性通道而发挥作用,阻断离子型通道将导致肌肉松弛和萎缩。但这种干扰作用不会导致神经的退行性变,是可逆的。通过分析文献,对注射BTX-A的适应证及禁忌证、使用剂量、注射部位、注射点位数、临床疗效、不良反应等方面进行总结与探讨,以期为BTX-A治疗难治性OAB提供更详实的参考与指导。Intravesical injection of botulinum toxin-A(BTX-A)is a safe and effective treatment for patients with refractory overactive bladder(OAB).It works by interfering with nerve conduction calcium-dependent channels and blocking ionic channels to cause muscle relaxation and atrophy.This interference does not cause neurological degeneration.It also is reversible.Through literature analysis,the indications and contraindications of BTX-A injection,BTX-A dose,injection site,injection point,clinical efficacy,adverse reactions and other aspects are summarized and discussed.We wish to provide more detailed reference and guidance for BTX-A treatment of refractory OAB.

关 键 词：肉毒毒素A 膀胱过度活动症 膀胱 注射 

分 类 号：R694.5[医药卫生—泌尿科学]