三项血清指标水平与肺癌合并放射性肺炎患者病情程度及预后的关系  

Relationship between the levels of three serum indicators and the severity and prognosis of patients with lung cancer complicated by radiation pneumonitis

作　　者：张杏乔 李伟明[1] 张晶[1] 李雅娟 ZHANG Xing-qiao;LI Wei-ming;ZHANG Jing;LI Ya-juan(The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450000

出　　处：《实用医院临床杂志》2025年第2期104-108,共5页Practical Journal of Clinical Medicine

基　　金：河南省中医药拔尖人才培养项目(编号:2022ZYBJ18)。

摘　　要：目的探讨血清涎液化糖链抗原(KL-6)、转化生长因子-β1(TGF-β1)、细胞间粘附分子-1(ICAM-1)水平与肺癌合并放射性肺炎患者病情程度及预后的关系。方法我院2020年10月至2023年10月收治的205例肺癌合并放射性肺炎患者,根据病情程度分为重度组、中度组及轻度组,比较三组血清KL-6、TGF-β1、ICAM-1水平,再结合重度组患者预后情况分为恢复组和肺纤维化组,比较两亚组血清KL-6、TGF-β1、ICAM-1水平,分析血清KL-6、TGF-β1、ICAM-1水平与肺癌合并放射性肺炎患者病情程度及预后的相关性。采用ROC曲线分析血清KL-6、TGF-β1、ICAM-1水平对肺癌合并放射性肺炎患者预后的预测效能。结果重度组血清KL-6、TGF-β1、ICAM-1水平均高于中度组、轻度组(P<0.05),中度组血清KL-6、TGF-β1、ICAM-1水平均高于轻度组(P<0.05);肺纤维化组血清KL-6、TGF-β1、ICAM-1水平均高于恢复组(P<0.05)。血清KL-6、TGF-β1、ICAM-1水平与肺癌合并放射性肺炎患者病情程度呈正相关,与患者预后呈负相关(P<0.05)。血清KL-6、TGF-β1、ICAM-1以及联合检查曲线AUC明显大于参考线(P<0.05),其截断值分别为1.80 U/L、277.24 pg/ml、779.74 ng/ml。结论血清KL-6、TGF-β1、ICAM-1水平与肺癌合并放射性肺炎患者病情程度及预后具有一定相关性,血清KL-6、TGF-β1、ICAM-1水平越高,患者病情越严重,临床可通过检测血清KL-6、TGF-β1、ICAM-1水平,早期诊断放射性肺炎,还为其治疗提供有利参考。Objective To explore the correlation between the levels of serum Krebs yon den Lungen-6(KL-6),transforming growth factor-β1(TGF-β1)and intercellular adhesion molecule-1(ICAM-1)and the disease severity and prognosis of patients with lung cancer complicated with radiation pneumonitis.Methods Clinical data of 205 patients with lung cancer and radiation pneumonitis in our hospital from October 2020 to October 2023 were selected.According to the disease severity,the patients were divided into a severe group,a moderate group and a mild group.The levels of serum KL-6,TGF-β1 and ICAM-1 were compared among the three groups.The patients in the severe group were further classified into a recovery subgroup and a pulmonary fibrosis subgroup according to prognosis of the patients.Levels of serum KL-6,TGF-β1 and ICAM-1 were compared between the two subgroups.The correlation be-tween the levels of serum KL-6,TGF-β1 and ICAM-1 and the disease severity and prognosis of patients with lung cancer complicated with radiation pneumonitis was analyzed.ROC curve analysis was used to analyze the predictive efficiency of serum KL-6,TGF-β1 and ICAM-1 levels for the prognosis of patients with lung cancer and radiation pneumonitis.Results The levels of serum KL-6,TGF-β1 and ICAM-1 of patients in the severe group were higher than those in the moderate group and the mild group(P<0.05),and the above levels in the moderate group were higher than those in the mild group(P<0.05).Serum KL-6,TGF-β1 and ICAM-1 levels in the pul-monary fibrosis subgroup were higher compared with those in the recovery subgroup(P<0.05).Serum levels of KL-6,TGF-β1 and ICAM-1 were positively correlated with disease severity of lung cancer with radiation pneumonitis(P<0.05),and were negatively cor-related with the prognosis of the patients(P<0.05).The AUCs of serum KL-6,TGF-β1,ICAM-1 and combined detection were signif-icantly greater than the reference line(P<0.05).The cut-off values were 1.80 U/L,277.24 pg/mL and 779.74 ng/mL respectively.Conclusions Serum KL-6,T

关 键 词：涎液化糖链抗原 转化生长因子-β1 细胞间粘附分子-1 肺癌 放射性肺炎 病情程度 预后 

分 类 号：R734.2[医药卫生—肿瘤]