四川地区14460例就诊患者人乳头瘤病毒感染的流行病学调查  

Epidemiological investigation of human papillomavirus infection in 14460 visiting patients in Sichuan area

作　　者：李竹 史丽娜 刘珊 李晨钟 LI Zhu;SHI Li-na;LIU Shan;LI Chen-zhong(College of Medical Technology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China;Medical Genetics Center,Sichuan Academy of Medical Sciences&Sichuan People's Hospital(Affiliated Hospital of University of Elec-tronic Science and Technology of China),Chengdu 610072,China;The Chinese University of Hong Kong(Shenzhen Campus),Shenzhen 518000,China)

机构地区：[1]成都中医药大学医学技术学院,四川成都610075 [2]电子科技大学医学院,四川成都611731 [3]四川省医学科学院·四川省人民医院(电子科技大学附属医院)医学遗传中心,四川成都610072 [4]香港中文大学(深圳校区),广东深圳518000

出　　处：《实用医院临床杂志》2025年第2期135-139,共5页Practical Journal of Clinical Medicine

基　　金：四川省干部保健课题(编号:川干研2023-214)。

摘　　要：目的通过对四川省人民医院人乳头瘤病毒(HPV)受检者进行分型检测,探讨四川地区人群HPV感染情况、亚型分布及不同人群差异分析。方法采用流式荧光杂交技术对2023年1~12月四川省人民医院就诊的14460例男女HPV受检者的分泌物样本进行HPV-DNA分型检测,包括17种高危型、10种低危型共27种型别。结果分别检测男性2806例和女性11654例,HPV阳性率分别为41.38%和25.76%,男、女性感染率居前5位的基因型分别为HPV6(17.00%)、HPV11(9.69%)、HPV59(3.03%)、HPV16(2.60%)、HPV52(2.60%)和HPV52(4.66%)、HPV58(3.30%)、HPV53(2.70%)、HPV16(2.44%)、HPV39(1.52%)型。男性以低危型HPV感染最为常见,占比为22.67%;女性以高危型HPV感染最为常见,占比为19.30%,其中以单重高危型最为常见,多重感染以混合感染最为常见,与男性一致。结论四川地区HPV总体流行率较高,其分布呈现出不同年龄和不同性别的HPV感染率和亚型分布存在差异。男性HPV感染率尤其值得临床关注,男性有必要常规参与HPV疫苗接种和筛查。Objective To investigate the human papillomavirus(HPV)infection status,subtype distribution,and analysis of differences among different populations in Sichuan by typing HPV subjects in Sichuan Provincial People's Hospital.Methods Flow fluorescence hybridization technology was used to conduct HPV-DNA typing detection on the secretion samples of 14,460 male and female HPV test subjects who visited Sichuan Provincial People's Hospital from January to December 2023.The tests included 17 highrisk types and 10 low-risk types.Total was 27 types.Results The tests were performed on 2806 men and 11654 women.HPV-positive rates in men was 41.38%and in women was 25.76%.The top 5 genotypes of infection in men were HPV6(17.00%),HPV11(9.69%),HPV59(3.03%),HPV16(2.60%)and HPV 52(2.60%),The top 5 genotypes of infection in women were HPV 52(4.66%),HPV 58(3.30%),HPV 53(2.70%),HPV 16(2.44%)and HPV 39(1.52%).Low-risk HPV infections were most common in males(22.67%).High-risk HPV infections were most common in females(19.30%).Among the women,single high-risk type was the most common.Among multiple infections,mixed infection is the most common.These were consistent with men.Conclusions The overall prevalence of HPV in Sichuan was high.Its distribution shows differences in the prevalence and subtype distribution of HPV infection among different age groups and genders.The prevalence of HPV infection in men is of particular clinical concern.Therefore,it is necessary for men to routinely participate in HPV vaccination and screening.

关 键 词：人乳头瘤病毒 基因分型 感染 性别 疫苗 

分 类 号：R446.5[医药卫生—诊断学]