天然多糖基微针在慢性伤口治疗中的研究进展  

Research Progress in Natural Polysaccharide-Based Microneedles for Repairing Chronic Wounds

作　　者：吴文浩 杨宽[1,3,4] 伍静 覃淮 杨晨鑫 Wu Wenhao;Yang Kuan;Wu Jing;Qin Huai;Yang Chenxin(Xi’an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs1,Xi’an Medical University,Xi’an,710021;School of Pharmacy,Chengdu Medical College,Chengdu,610500;College of Pharmacy,Xi’an Medical University,Xi’an,710021;Institute of Drug Research,Xi’an Medical University,Xi’an,710021)

机构地区：[1]西安医学院西安市多靶协同抗高血压创新药物研制重点实验室,西安710021 [2]成都医学院药学院,成都610500 [3]西安医学院药学院,西安710021 [4]西安医学院药物研究所,西安710021

出　　处：《化学通报(中英文)》2025年第3期241-254,共14页Chemistry

基　　金：陕西省重点研发计划项目(2021ZDLSF03-05);陕西省教育厅青年创新团队项目(23JP155);陕西高校青年创新团队建设项目(2022-85);西安医学院校级科技创新团队(2021TD03、07);陕西省教育厅服务地方专项项目(23JC060);西安医学院专创融合创新创业课程(2024ZCRH-04);西安医学院校级科研计划项目(2024NLTS118)资助。

摘　　要：慢性伤口中复杂的微环境致使创面难以愈合,给患者带来很大的负担。在当下的治疗手段中多采用贴剂、涂剂和乳膏等,但大多数治疗效果较差,因为药物分子需克服皮肤角质层的阻碍到达作用部位,且伤口结痂和细菌形成的生物膜进一步阻碍药物渗透。微针作为一种新型的经皮给药方法,克服以往剂型的不足,实现无痛给药,可以物理突破皮肤屏障,将药物递送到真皮组织。在微针的制备中,天然多糖因其优异的理化性质(生物相容性、可降解性、无毒性)而备受关注。本文简单介绍了微针的种类和制备方法,深入讨论了以不同天然多糖为基质材料构建的微针系统在促进慢性伤口修复方面的研究进展,展望了天然多糖基微针未来的应用前景。The complex microenvironment in chronic wounds makes it difficult for the wound to healing,which imposes a great burden on patients.In current treatment methods,patches,coatings,and creams are commonly used,but most of them have poor therapeutic effects and are burdensome,because drug molecules need to overcome the obstruction of the stratum corneum of the skin to reach the site of action,and the biofilm formed by wound scab and bacteria further hinders drug penetration.As a new type of transdermal drug delivery method,microneedles overcome the shortcomings of previous dosage forms,achieve painless drug delivery,physically break through the skin barrier,and effectively deliver drugs to the dermal tissue.In the preparation of microneedles,natural polysaccharides have attracted much attention due to their excellent physicochemical properties.In this review,the types and preparation methods of microneedles are briefly introduced,and the research progress in microneedle systems constructed with different natural polysaccharides as matrix materials for promoting chronic wound repair is discussed in depth.The future application prospects of natural polysaccharide based microneedles are also discussed.

关 键 词：天然多糖 微针 慢性伤口 

分 类 号：TH77[机械工程—仪器科学与技术] R641[机械工程—精密仪器及机械]