持续气道正压通气对不同程度OSAHS伴轻度认知障碍患者认知功能的影响  

The Effect of Continuous Positive Airway Pressure on Cognitive Function in Patients with Different Degrees of OSAHS and Mild Cognitive Impairment

作　　者：赵阿敏 余刚 ZHAO Amin;YU Gang(Department of Respiratory and Critical Care Medicine,Xi’an Central Hospital,Xi’an 710000,China;不详)

机构地区：[1]西安市中心医院呼吸与危重症医学科,陕西西安710000

出　　处：《中国医学创新》2025年第8期104-108,共5页Medical Innovation of China

基　　金：2023年西安市中心医院科研基金资助项目(2023YB03)。

摘　　要：目的:阻塞性睡眠呼吸暂停低通气综合征(OSAHS)多伴有轻度认知障碍问题,对此分析持续气道正压通气(CPAP)治疗方法对患者认知功能的影响。方法:选取2022年6月—2023年1月西安市中心医院收治的OSAHS伴轻度认知障碍患者60例为研究对象,根据睡眠暂停低通气指数(AHI)和夜间脉搏血氧饱和度(SpO_2)将其分为观察1组轻度OSAHS伴轻度认知障碍,观察2组中度OSAHS伴轻度认知障碍,观察3组重度OASHA伴轻度认知障碍,各20例。三组研究对象均接受CPAP治疗,观察治疗前后蒙特利尔认知评估量表(MoCA)变化及多导睡眠监测(PSG)相关指标变化。结果:与治疗前相比,三组治疗1、3、6个月后MoCA评分均提高,差异均有统计学意义(P<0.05),但组间治疗1、3、6个月后对比差异均无统计学意义(P>0.05)。治疗前,观察3组AHI高于观察1组、观察2组,三组AHI差异有统计学意义(P<0.05),其余夜间最低脉氧、睡眠潜伏期、非快速眼动1期(N1)+非快速眼动2期(N2)占总睡眠时间百分比[(N1+N2)%]、非快速眼动3期(N3)占总睡眠时间百分比(N3%)值相比,差异均无统计学意义(P>0.05),三组治疗6个月后AHI、睡前潜伏期、(N1+N2)%均降低,夜间最低脉氧、N3%均升高,且观察1组AHI、睡眠潜伏期、(N1+N2)%均低于观察2组、观察3组;观察1组夜间最低脉氧、N3%均高于观察2组、观察3组,差异均有统计学意义(P<0.05)。结论:对于OSAHS伴轻度认知障碍患者采取CPAP治疗方案,有助于改善患者的认知功能及睡眠呼吸参数,且轻度OSAHS伴轻度认知障碍患者恢复更理想。Objective:Obstructive sleep apnea hypopnea syndrome(OSAHS)is often accompanied by mild cognitive impairment.To analyze the effect of continuous positive airway pressure(CPAP)treatment on cognitive function of patients.Method:Sixty patients with OSAHS and mild cognitive impairment admitted to Xi’an Central Hospital from June 2022 to January 2023 were selected as the study subjects,and grouped according to sleep apnea hypopnea index(AHI)and nightly pulse oxygen saturation(SpO2),they were divided into observation group 1 with mild OSAHS and mild cognitive impairment,observation group 2 with moderate OSAHS and mild cognitive impairment,and observation group 3 with severe OASHA and mild cognitive impairment,with 20 cases in each group.All three groups of study subjects received CPAP treatment,and changes in the Montreal cognitive assessment scale(MoCA)and polysomnography(PSG)related indicators were observed before and after treatment.Result:Compared with before treatment,the MoCA scores of the three groups were improved after 1 month,3 and 6 months of treatment,the differences were statistically significant(P<0.05),however,there were no significant differences between the two groups after 1 month,3 and 6 months of treatment(P>0.05).Before treatment,the AHI of the observation group 3 was higher than that of the observation group 1 and the observation group 2,the AHI of the three groups was statistically significant(P<0.05);there were no statistically significant differences in the lowest pulse oxygen at nights,sleep latency,the percentage of non-rapid eye movement stage 1(N1)+non-rapid eye movement stage 2(N2)in total sleep time[(N1+N2)%],and the percentage of non-rapid eye movement stage 3(N3)in total sleep time(N3%)between the two groups(P>0.05);after treatment,the AHI,sleep latency,(N1+N2)%of the three groups decreased,the lowest pulse oxygen at night and N3%increased,and the AHI,sleep latency,(N1+N2)%of the observation group 1 were lower than those of the observation group 2 and the observation group 3;the lowest

关 键 词：持续气道正压通气 阻塞性睡眠呼吸暂停低通气综合征 认知功能 多导睡眠监测 

分 类 号：R76[医药卫生—耳鼻咽喉科]