替诺福韦、拉米夫定、依非韦伦联合中医药穴位贴治疗艾滋病的临床有效性及CD4+T淋巴细胞计数、HIV病毒载量的研究  

Study on the Clinical Effectiveness of Tenofovir,Lamivudine,and Efavirenz Combined with Traditional Chinese Medicine Acupoint Application in the Treatment of AIDS,and Its Impact on CD4+T Lymphocyte Count and HIV Viral Load

作　　者：罗景贤 周淦梧 梁小兰 卢潇宇 陈捷 LUO Jingxian;ZHOU Ganwu;LIANG Xiaolan;LU Xiaoyu;CHEN Jie(Department of Infectious Diseases,The People’s Hospital of Cenxi City,Cengxi,Guangxi 543200,China;Party and Government Office,Cenxi People’s Hospital,Cenxi,Guangxi 543200,China)

机构地区：[1]岑溪市人民医院感染性疾病科,广西岑溪543200 [2]岑溪市人民医院党政办公室,广西岑溪543200

出　　处：《中国医药指南》2025年第9期14-16,共3页Guide of China Medicine

基　　金：科技惠民科技专项(2021F01033)。

摘　　要：目的探究替诺福韦、拉米夫定、依非韦伦联合中医药穴位贴治疗艾滋病的疗效及对CD4+T淋巴细胞计数、HIV病毒载量的影响。方法将岑溪市人民医院关爱门诊收治的艾滋病患者102例(2019年2月至2023年2月)根据治疗时间分为观察组、对照组。予对照组替诺福韦、拉米夫定、依非韦伦治疗,观察组在对照组的基础上联合中医穴位贴治疗,对比两组疗效、CD4+T淋巴细胞计数、HIV病毒载量及不良反应。结果观察组总有效率高于对照组(P<0.05);治疗后两组CD4+T淋巴细胞计数均升高且观察组高于对照组(P<0.05);治疗后两组HIV病毒载量均降低且观察组低于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论在艾滋病患者中应用替诺福韦、拉米夫定、依非韦伦联合中医药穴位贴效果较好,有利于减少HIV病毒载量和不良反应,提高患者的免疫力。Objective To investigate the efficacy of tenofovir,lamivudine,efavirenz combined with traditional Chinese medicine(TCM)acupoint application in the treatment of AIDS,as well as its impact on CD4+T lymphocyte count and HIV viral load.Methods A total of 102 AIDS patients admitted to the Care Clinic of Cenxi People’s Hospital(February 2019 to February 2023)were divided into Observational Group and Control Group based on their treatment time.Control Group received tenofovir,lamivudine,and efavirenz,while Observational Group received the same antiviral regimen combined with TCM acupoint application.The efficacy,CD4+T lymphocyte count,HIV viral load,and adverse reactions were compared between the two groups.Results The total effective rate was higher in Observational Group than in Control Group(P<0.05).After treatment,the CD4+T lymphocyte count increased in both groups,with Observational Group showing a higher count than Control Group(P<0.05).The HIV viral load decreased in both groups after treatment,with Observational Group having a lower viral load than Control Group(P<0.05).The incidence of adverse reactions was lower in Observational Group than in Control Group(P<0.05).Conclusions The combined use of tenofovir,lamivudine,efavirenz,and TCM acupoint application in AIDS patients yields better results,helping to reduce HIV viral load and adverse reactions while enhancing patients’immunity.

关 键 词：替诺福韦 拉米夫定 依非韦伦 中医药穴位贴 艾滋病 CD4+T淋巴细胞 HIV病毒载量 

分 类 号：R512.91[医药卫生—内科学]