妊娠期糖尿病患者孕中期血脂水平变化对围生结局的影响  

The Influence of the Changes of Blood Lipid Levels in Pregnant Women with Diabetes on Perinatal Outcomes

作　　者：王璐璐 宋盼 董亚诺 WANG Lulu;SONG Pan;DONG Ya’nuo(Obstetrics and Gynecology Department,Ganyu District People’s Hospital,Lianyungang City,Lianyungang,Jiangsu 222100,China)

机构地区：[1]连云港市赣榆区人民医院妇产科,江苏连云港222100

出　　处：《中国医药指南》2025年第9期91-93,共3页Guide of China Medicine

摘　　要：目的探究妊娠期糖尿病(GDM)患者孕中期血脂水平变化对围生结局的影响。方法选择389例GDM患者为对象作为观察组,均为2023年1月至2024年6月连云港市赣榆区人民医院收治,选择同期124名健康产妇为对照组,收集两组相关临床资料,对比两组孕中期血糖水平、血脂水平及围生期结局。结果观察组空腹血糖、餐后1 h血糖、餐后2 h血糖水平高于对照组(P<0.05);观察组总胆固醇、甘油三酯、低密度脂蛋白胆固醇高于对照组,高密度脂蛋白胆固醇低于对照组(P<0.05);观察组妊娠期高血压、早产、胎膜早破、产后出血、巨大儿发生率高于对照组(P<0.05),两组新生儿窒息发生率无统计学意义(P>0.05)。结论GDM患者孕中期糖脂代谢紊乱,血糖、血脂水平异常会增加不良围生结局发生风险。Objective To assess the effect of alterations in lipid profiles during the second trimester on perinatal outcomes in patients with gestational diabetes mellitus(GDM).Methods A cohort of 389 GDM patients from January 2023 to June 2024 was selected as the observation group,with 124 healthy pregnant women from the same period serving as the control group.Comprehensive clinical data for both cohorts were collated and subjected to comparative analysis,encompassing second-trimester glycemic and lipid profiles,as well as obstetric and neonatal outcomes.Results The fasting blood glucose,1-hour postprandial blood glucose,and 2-hour postprandial blood glucose levels in the observation group were significantly elevated compared to the control group(P<0.05).TC,TG,and LDL-C in the observation group were higher than those in the control group,and HDL-C was lower than those in the control group(P<0.05).The incidence of preterm delivery,premature rupture of membranes,gestational hypertension,postpartum hemorrhage,macrosomia,and neonatal asphyxia was also significantly higher in the observation group compared to the control group(P<0.05).Conclusions Pregnant individuals with GDM exhibit dyslipidemia and abnormalities in blood glucose and lipid levels during the second trimester,thereby elevating the risk of adverse perinatal outcomes.

关 键 词：妊娠期糖尿病 血脂水平 围生结局 血糖 不良结局 

分 类 号：R714.256[医药卫生—妇产科学]