急性心肌梗死术前冠心宁片加载给药对PCI术中无复流现象及心功能的影响  

Effects of Preoperative Loading of Guanxinning Tablet on No-Reflow Phenomenon and Cardiac Function During PCI in Acute Myocardial Infarction

作　　者：陆林 张颖 王颖 齐乐 LU Lin;ZHANG Ying;WANG Ying;QI Le(Department of Cardiovascular Medicine,Xinyi Hospital of Traditional Chinese Medicine,Xinyi,Jiangsu 221400,China)

机构地区：[1]新沂市中医医院心血管内科,江苏新沂221400

出　　处：《中国医药指南》2025年第9期136-138,共3页Guide of China Medicine

基　　金：徐州市中医药科技发展计划项目(XZYB2021036)。

摘　　要：目的探讨在急性心肌梗死(AMI)行急诊经皮冠状动脉介入治疗(PCI)的患者中,加载应用冠心宁片对术中无复流及心功能的影响。方法将新沂市中医医院收治的AMI设为本次研究对象,从中随机择取74例参与研究,就诊时间均在2021年11月至2024年4月,借助随机数表法将所有收治者分成两组,对照组与研究组各随机计入37例。对照组采用急诊PCI术前的常规处理,包括阿司匹林300 mg、替格瑞洛180 mg嚼服负荷,肝素钠注射液100 U/kg静脉注射。研究组在常规处理的基础上,联合冠心宁片展开治疗,剂量方法为4片加载给药。比较两组急诊PCI术中无复流的发生率、治疗前后炎症因子C反应蛋白、白细胞介素-6及心功能的变化。结果急诊PCI术中,研究组无复流发生率低于对照组(P=0.032);治疗12周后,两组心功能均有改善(P<0.05),且研究组优于对照组(P<0.05);治疗落实后,两个小组炎性指标均较治疗前降低,且研究组治疗后相较于对照组检测结果呈更低显示(P<0.05)。结论AMI行急诊PCI的患者,术前冠心宁片加载给药,可以有效地降低PCI术中无复流的发生,明显降低术后炎症因子的水平,更有效的改善心功能。Objective To investigate the effect of Guanxinning tablet on intraoperative reflow and cardiac function in patients with acute myocardial infarction undergoing emergency percutaneous coronary intervention(PCI).Methods A total of 74 patients with acute myocardial infarction admitted to the Cardiovascular Medicine of Xinyi hospital of Traditional Chinese Medicine were randomly selected to participate in the study.All patients were treated from November 2021 to April 2024.All patients were divided into two groups by means of random number table method,and 37 cases were randomly included in the control group and the study group.The control group received routine treatment before emergency PCI,including aspirin 300 mg,ticagrelor 180 mg chewing load,heparin sodium injection 100 U/kg intravenous injection.On the basis of conventional treatment,the study group combined Guanxin tablets to start the treatment,and the dose was 4 tablets loaded.The incidence of non-reflow,the changes of inflammatory factors C-reactive protein,interleukin-6 and cardiac function before and after PCI were compared between two groups.Results The incidence of no reflow in the study group was lower than that in the control group(P=0.032).After 12 weeks of treatment,the cardiac function of both groups was improved(P<0.05),and the study group was better than the control group(P<0.05).After the implementation of treatment,the inflammatory indexes of both groups were lower than before treatment,and the test results of the study group after treatment were lower than those of the control group(P<0.05).Conclusions In patients with acute myocardial infarction undergoing emergency PCI,the loading and administration of Guanxinning tablet before surgery can effectively reduce the occurrence of no reflow during PCI,significantly reduce the level of postoperative inflammatory factors,and more effectively improve cardiac function.

关 键 词：急性心肌梗死 冠心宁片 急诊经皮冠状动脉介入治疗 无复流 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]