贝沙格列净中间体的制备方法研究  

Study on the Preparation Method of Bexaglizin Intermediate

作　　者：张雷刚 林兴龙 黄正伟 解鸣涛 刘红坤 夏海建 ZHANG Leigang;LIN Xinglong;Huang Zhengwei;XIE Mingtao;LIU Hongkun;XIA Haijian(Zhejiang YongTai Technology Co.,Ltd.,Linhai 317016,China)

机构地区：[1]浙江永太科技股份有限公司,浙江临海317016

出　　处：《生物化工》2025年第1期85-88,共4页Biological Chemical Engineering

基　　金：2023年临海市专利导航项目(ZLDH2023-005)。

摘　　要：本文研究了一种贝沙格列净中间体的制备方法。以5-溴-2-氯苯甲酰氯(化合物Ⅳ)为原料,首先与卤苯发生傅克酰基化反应,然后再经取代反应和还原反应等步骤获得高收率、高质量的贝沙格列净中间体(5-溴-2-氯苯基)[(4-(2-环丙氧基)乙氧基苯基)甲烷](化合物I)。本制备方法具有反应选择性高,物料廉价易得,收率高和产品质量好等优势,并成功解决了传统工艺物料反应选择性低、物料成本高和产物难提纯等生产问题。In this article,the preparation method of besaglitazine intermediate is described.5-bromo-2-chlorobenzoyl chloride(compoundⅣ)is used as raw material,and Fouke acylation reaction with halobenzene is firstly carried out,then the intermediate(5-bromo-2-chlorophenyl)[4-(2-cyclopropoxy)ethoxyphenyl]methane(compoundⅠ)with high yield and high quality Is obtained by substitution reaction and reduction reaction.The preparation method has the advantages of high reaction selectivity,cheap and easy to obtain materials,high yield and good product quality,and successfully solved the problems of low reaction selectivity,high cost of materials and difficult purification of products.

关 键 词：贝沙格列净中间体 制备方法 (5-溴-2-氯苯基)[4-(2-环丙氧基)乙氧基苯基]甲烷 

分 类 号：O621.3[理学—有机化学]