显微外科断指再植术后血清炎性因子水平与疼痛程度的相关性研究  

Correlation studies between serum inflammatory factors and pain degree after microsurgical finger replantation

作　　者：蔡正强 陈建辉 林小富 王家林 蒋仲松 张可可 赵军[2] CAI Zhengqiang;CHEN Jianhui;LIN Xiaofu(Department of Hand and Food Microsurgery,Dongguan Xiegang Hospital,Dongguan,Guangdong,523590,China)

机构地区：[1]东莞市谢岗医院手足显微血管外科,广东东莞523590 [2]南方医科大学第十附属医院足踝修复重建骨科,广东东莞523000

出　　处：《实用手外科杂志》2025年第1期18-21,共4页Journal of Practical Hand Surgery

基　　金：东莞市社会发展科技项目(项目编号:20221800902022)。

摘　　要：目的探讨显微外科断指再植术后血清炎性因子与疼痛程度相关性。方法回顾性分析2022年1月-2024年5月收治的行显微外科断指再植术52例患者的临床资料,均按照规范手术治疗,术后进行1周随访,统计术后断指再植成活与坏死情况。手术前后均采集静脉血液并离心分离血清,检测血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)水平;手术前后应用视觉模拟评分法(VAS)评价疼痛程度。对手术前后的血清炎性因子检测结果、VAS评分进行比较。对比手术前后不同VAS评分者的血清炎性因子检测情况,并应用Pearson分析术后炎性因子与疼痛程度的相关性。结果52例患者术后断指成活49例(94.23%),坏死3例(5.77%)。术后的血清IL-6、hs-CRP、PCT水平低于术前(P<0.05),不同的VAS评分者评分越高手术前后血清各项炎性因子水平越高(P<0.05)。Pearson相关性分析,显微外科断指再植术后血清IL-6、hs-CRP、PCT水平与VAS评分均成正相关(r=0.715,0.755,0.734,P<0.05)。结论显微外科断指再植术后血清炎性因子水平较治疗前明显降低,疼痛评分较术前降低,术后血清炎性因子水平与疼痛程度联系紧密,炎性的控制可减轻疼痛程度。Objective To explore the correlation between serum inflammatory factors and pain degree after microsurgical finger replantation.Methods The clinical data of 52 patients with microsurgical finger replantation from January 2022 to May 2024 were retrospectively analyzed.All patients were treated according to standard surgical treatment,and were followed up for 1 week after operation.The survival and death of postoperative finger replantation were statistically analyzed.Before and after treatment,venous blood was collected and serum was centrifuged to detect the levels of serum interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT).Visual analogue scale(VAS)was used to evaluate the pain degree before and after treatment.The serum inflammatory factors and VAS scores before and after treatment were compared.The serum inflammatory factors of patients with different VAS scores before and after treatment were compared,and Pearson correlation analysis was used to analyze the correlation between postoperative inflammatory factors and pain degree.Results In the 52 patients with postoperative finger amputation,49(94.23%)survived and 3(5.77%)died.The serum levels of IL-6,hs-CRP and PCT after treatment were lower than those before treatment(P<0.05).Pearson correlation analysis showed that the serum levels of IL-6,hs-CRP and PCT after microsurgical replantation of severed fingers were positively correlated with VAS scores(r=0.715,0.755,0.734,all P<0.05).Conclusion The serum levels of inflammatory factors after microsurgical replantation of severed fingers are significantly lower than those before treatment,and the pain scores are lower than those before operation.The serum levels of inflammatory factors after operation are closely related to the pain degree,and the control of inflammation can reduce the pain degree.

关 键 词：显微外科断指再植术 炎性因子 疼痛程度 

分 类 号：R65[医药卫生—外科学]