Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration  

作　　者：Sung Won Ko Joshua Lee Ji Yeon Lee Jeong Hwi Cho Sunny Lee Hak Su Jang Chan Hee Park Hyun Jin Tae Cheol Sang Kim Young Min Oh 

机构地区：[1]Department of Bionanosystem Engineering,Jeonbuk National University,Jeonju,Republic of Korea [2]Department of Bionanotechnology and Bioconvergence Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea [3]Department of Mechanical Design Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea [4]College of Veterinary Medicine and Bio-safety Research Institute,Jeonbuk National University,Iksan,Republic of Korea [5]R&D Center,CGBIO Inc,Seongnam,Republic of Korea [6]Division of Mechanical Design Engineering,Jeonbuk National University,Jeonju,Republic of Korea [7]Department of Neurosurgery,Research Institute of Clinical Medicine,Jeonbuk National University Medical,School and Hospital,Jeonju,Republic of Korea

出　　处：《Journal of Materials Science & Technology》2024年第32期246-259,共14页材料科学技术(英文版)

基　　金：supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(Project No.2016R1C1B2008296);It was also partially supported by the Na-tional Research Foundation of Korea(NRF)grant funded by the Korean Ministry of Education(Nos.NRF-2021R1I1A1A01047751 and RS-2023-00240020).

摘　　要：Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material.To overcome this,compact fibrous DBM/polymer(fDBM)composites were prepared via electrospinning.Then,by exploiting the catalytic decomposition of hydrogen peroxide,oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone(Op-fDBM).These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth.In vivo evaluations reveal that fDBM increased bone volume by 41.7%while Op-fDBM increased bone volume by 68.6%.Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.

关 键 词：Demineralized bone matrix Hierarchical networks Catalytic decomposition Bone regeneration 

分 类 号：TB3[一般工业技术—材料科学与工程]