Advances and prospects of 3D printed antibacterial bone implants:A systematic review  

作　　者：Xin Liu Sihan Lu Tianlin Wang Xiaohong Wang Ke Yang Huazhe Yang 

机构地区：[1]China Medical University(CMU),Shenyang 110122,China [2]Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China

出　　处：《Journal of Materials Science & Technology》2024年第33期227-242,共16页材料科学技术(英文版)

基　　金：supported by the Foundation of the Education Department of Liaoning Province in China(No.JYTMS20230134);the Key Research&Development Project of Liaoning Province(No.2018225082);the National Natural Sci-ence Foundation of China(Nos.81500897 and 81571832);the National Key Research and Development Program of China(No.2022YFC2406003).

摘　　要：Bone defect is a serious problem for clinical orthopedics,and the construction of bone implants with ideal size,shape,structure and demanded biofunctions,etc.,is of great importance for bone repairs.Especially,the endowment of implants with antibacterial activities is a promising strategy for the potential occurrence of infections during and/or after bone graft surgery.Three-dimensional(3D)printing,a hot technological strategy in tissue engineering,is increasingly applied in manufacturing various personalized,controlled and precise bone implants.However,significant challenges remain in overcoming infections.In this systematic review,different 3D-printed antibacterial bone implants are critically reviewed,and a general summary of the latest researches is systemically expounded,in which different antibacterial agents are involved:(i)inorganic;(ii)organic micromolecule;(iii)organic macromolecule;(iv)“functionassist”materials.Moreover,designments of printing processes,loading methods of antibacterial agents,functional treatments of bone implants,and related antibacterial mechanisms are also discussed.Overall,it is demonstrated that antibacterial 3D-printed bone implants exhibit excellent bone regeneration and bacterial resistance.Especially,the limitations and future expectations on the strategies and the development of the“programmed”antibacterial implants,are highlighted.This systematic review can provide a comprehensive understanding and insightful guidance for further exploring promising antimicrobial bone implants.

关 键 词：3D printing BONE IMPLANTS INFECTION ANTIBACTERIAL 

分 类 号：R68[医药卫生—骨科学]