血清衰老标记蛋白30对高血压合并慢性心力衰竭的诊断价值  

The diagnostic value of serum senescence marker protein-30 for patients with hypertension accompanied by chronic heart failure

作　　者：盛春梅[1] 陈厚良 樊宗成 程小兵[1] SHENG Chunmei;CHEN Houliang;FAN Zongchen;CHENG Xiaobin(Department of Cardiovascular Diseases,Third People’s Hospital of Hefei,Hefei 236800,China)

机构地区：[1]合肥市第三人民医院心血管内科,230022

出　　处：《心肺血管病杂志》2025年第3期240-245,300,共7页Journal of Cardiovascular and Pulmonary Diseases

基　　金：安徽医科大学2021年科研基金资助项目(2021xkj125);合肥市卫生健康委2022年度应用医学研究项目(Hw2022yb024)。

摘　　要：目的:分析血清衰老标记蛋白30(senescence marker protein-30,SMP30)与高血压(hypertension,HP)合并慢性心力衰竭(chronic heart failure,CHF)发生风险的关联。方法:收集2023年7月至2023年11月,就诊于合肥市第三人民医院心血管内科HP患者405例的临床资料,根据是否合并CHF分成两组,为单纯的HP患者339例,HP伴CHF患者66例。采用Spearman或Pearson相关性分析评估血清SMP30与HP患者临床特征间的关联;采用多元Logistic回归评估血清SMP30与HP伴CHF发生风险的关联;采用ROC曲线评估不同指标对HP伴CHF发生的预测能力。结果:CHF血清SMP30水平显著高于单纯HP患者。随着高血压等级和NYHA评分升高,血清SMP30水平也逐渐升高。相关性分析表明,血清SMP30水平与HP患者血常规、肝功能、肾功能以及心肌酶谱指标显著相关。多元Logistic回归模型表明,血清SMP30水平升高,增加CHF的发生风险。ROC曲线提示,尽管血清SMP30对CHF的预测性能稍低于NT-proBNP和LVEF,但SMP30联合NT-proBNP或LVEF的预测性能是高于单一指标。结论:HP+CHF患者血清SMP30水平显著高于单纯HP患者,血清SMP30水平与HP患者的严重程度呈正相关,血清SMP30水平升高增加HP患者发生CHF的风险。血清SMP30可用作HP伴CHF患者诊断的一个血清分子标志物。Objective:To explore the correlations between serum senescence marker protein-30(SMP30)and the risk of hypertension(HP)patients accompanied by chronic heart failure(CHF).Methods:All 405 HP patients were enrolled from Department of Cardiovascular Diseases in the Third People’s Hospital of Hefei from July 2023 to November 2023.Blood specimens and clinical characteristics were collected.According to accompanied by CHF or not,all precipitants were divided into HP and HP+CHF groups.Among them,66(16.3%)cases were patients with HP+CHF.The relationships between serum SMP30 and clinical characteristics were assessed through Spearman or Pearson Correlative analysis.The correlations between serum SMP30 and the risk of CHF was explored via logistic regression model.The predictive powers of different indicators CHF were analyzed by receiver operating characteristic(ROC)curve among HP patients.Results:The level of serum SMP30 was obviously increased in HP+CHF patients compared with HP subjects.Besides,the level of serum SMP30 was gradually elevated in parallel with the hypertension grade and NYHA score in HP patients.Spearman or Pearson Correlative analyses revealed there were strong associations of serum SMP30 with the indicators of blood routine,liver function,renal function,and myocardial enzymes in HP patients.Multivariate logistic regression model suggested that serum higher SMP30 elevated the risk of CHF in HP patients.Although the predictive power of serum SMP30 for CHF was weakly lower than those in NT-proBNP and LVEF in HP subjects,the combination between serum SMP30 with NT-proBNP and LVEF upregulated the predictive capacities for HP+CHF compared with the single indicator via ROC curve.Conclusions:Serum SMP30 was elevated in HP+CHF patients compared with HP patients.Serum SMP30 was positively associated with the severity in HP patients.Serum higher SMP30 elevated the risk of CHF among HP patients.Therefore,serum SMP30 may be used as a diagnostic biomarker in HP+CHF patients.

关 键 词：慢性心力衰竭 高血压 衰老标记蛋白30 左心室射血分数 严重程度 

分 类 号：R54[医药卫生—心血管疾病]