孕期新污染物暴露对胎儿发育影响的研究进展  

Research progress on effect of prenatal exposure to emerging pollutants on fetal development

作　　者：段婧茹 赵岩 金莉萍[1] Duan Jingru;Zhao Yan*;Jin Liping*(Obstetrics&Gynecology Hospital of Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院,上海200090

出　　处：《生物医学转化》2025年第1期20-28,35,共10页Biomedical Transformation

基　　金：国家自然科学基金面上项目(82173533,81730039,82071653)。

摘　　要：新污染物对人体健康的潜在危害日益受到关注,已成为环境与健康领域的研究热点。新污染物主要包括持久性有机污染物、环境内分泌干扰物、抗生素和微塑料。与传统污染物相比,新污染物具有更强的环境持久性、生物累积性和生物毒性,其种类在不断增加且管理措施尚不完善。新污染物能够通过胎盘屏障进入胎儿体内,对胎儿的发育产生不利影响,增加多种不良出生结局发生的风险。本文系统总结了孕期新污染物暴露对胎儿宫内发育的不利影响,并对未来的研究方向进行了展望。The potential health risks of emerging pollutants are increasingly gaining attention and have become a research hotspot in the fields of environmental and health sciences.Emerging pollutants mainly include persistent organic pollutants,environmental endocrine disruptors,antibiotics,and microplastics.Compared with traditional pollutants,emerging pollutants demonstrate greater environmental persistence,bioaccumulation potential,and biotoxicity.Their diversity is continuously expanding,while regulatory measures remain inadequate.Emerging pollutants can cross the placental barrier and enter the fetus,adversely affecting fetal development and increasing the risk of various adverse birth outcomes.This paper systematically summarizes the adverse effects of prenatal exposure to emerging pollutants on fetal development and provides an outlook on future research directions.

关 键 词：孕期暴露 胎儿发育 新污染物 不良出生结局 

分 类 号：R114[医药卫生—卫生毒理学]