孕期多金属暴露与子代健康  

Prenatal multi-metal exposure and offspring health

作　　者：周叶欣怡 金岚菲 陈光弟[1] Zhou Yexinyi;Jin Lanfei;Chen Guangdi*(School of Public Health,Zhejiang University,Hangzhou 310058,Zhejiang,China;Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310020,Zhejiang,China)

机构地区：[1]浙江大学公共卫生学院,浙江杭州310058 [2]浙江大学医学院附属邵逸夫医院,浙江杭州310020

出　　处：《生物医学转化》2025年第1期29-35,共7页Biomedical Transformation

摘　　要：近年来,孕期金属暴露对子代健康的影响已引起广泛关注。胎儿时期是环境污染物暴露的敏感窗口,即使低剂量的金属暴露也可能影响胎儿的正常生长发育,进而影响儿童期乃至成年期的健康。最新研究提示胎盘在金属暴露与子代健康的关联中起重要作用。在实际暴露情境中,孕妇常同时暴露于多种金属,因此,本文旨在系统梳理多金属暴露与子代健康之间的流行病学研究现状,并探讨胎盘在这一过程中可能涉及的潜在生物学机制。In recent years,the effects of prenatal metal exposure on offspring health have attracted widespread attention.The fetal period is a sensitive window for exposure to environmental pollutants,during which even low-dose metal exposure may disrupt normal growth and development,with potential health consequences extending from childhood into adulthood.Recent research has highlighted the crucial role of the placenta in mediating the relationship between metal exposure and offspring health.In real-world exposure scenarios,pregnant women are often exposed to multiple metals simultaneously.This review aims to systematically summarize current epidemiological research on the association between prenatal multi-metal exposure and offspring health and to explore the potential biological mechanisms involving the placenta in this process.

关 键 词：孕期 多金属暴露 子代健康 

分 类 号：R114[医药卫生—卫生毒理学]