新污染物致秀丽线虫跨代毒效应及机制研究进展  

Research progress on transgenerational toxicity induced by emerging pollutants and underlying mechanisms in Caenorhabditis elegans

作　　者：王宇星 王大勇[1] Wang Yuxing;Wang Dayong*(Southeast University School of Medicine,Nanjing 210009,Jiangsu,China)

机构地区：[1]东南大学医学院,江苏南京210009

出　　处：《生物医学转化》2025年第1期36-42,57,共8页Biomedical Transformation

基　　金：生态环境部环境污染健康风险评价重点实验室开放基金项目(KLEPHRA-2024-2)。

摘　　要：环境污染与人体健康的损害密切相关。近些年,新污染物的环境分布情况及其潜在毒性日益成为备受关注的焦点。跨代毒效应指外源化学物质或有害因素对生物体产生毒性后,通过特定机制传递给后代,导致其在发育、生理或行为等方面出现异常。新污染物对于生物体的毒性,不仅仅限于当代,可能会持续多代。秀丽线虫因为其非常短的生命周期以及对于环境暴露的高度敏感性,在跨代毒理学研究中具有重要价值。本综述首先介绍了新污染物暴露导致秀丽线虫的多方面跨代毒性,进而从跨代信号通讯调控、表观遗传信号调控、代谢信号调控、受体信号调控等方面,系统阐述了新污染物致秀丽线虫跨代毒性形成的分子机制。Environmental pollution is closely associated with adverse effects on human health.In recent years,growing attention has been directed toward the environmental distribution and potential toxicity of emerging pollutants.Transgenerational toxicity refers to the transmission of toxicity from exogenous chemicals or harmful factors to offspring through specific mechanisms,resulting in developmental,physiological,or behavioral abnormalities.The toxicity of emerging pollutants to organisms is not limited to the parental generation,but may persist across multiple generations.Due to its extremely short life cycle and high sensitivity to environmental exposure,Caenorhabditiselegans is highly valuable for transgenerational toxicology research.This review first introduces the multifaceted transgenerational toxicity induced by exposure to emerging pollutants in Caenorhabditiselegans.Then,it systematically elucidates the molecular mechanisms underlying the formation of this toxicity,focusing on the regulation of transgenerational signaling communication,epigenetic signaling,metabolic signaling,and receptor signaling.

关 键 词：新污染物 秀丽线虫 跨代毒性 分子机制 

分 类 号：R114[医药卫生—卫生毒理学]